23. Cheung MM, Chan JK, Lau WH, et al: Early stage nasal NK/T- cell lymphoma: Clinical outcome, prognostic factors, and the effect of treatment modality. Int J Radiat Oncol Biol Phys 54:182, 1998 24. Ko YH, Cho EY, Kim JE, et al: NK and NK-like T-cell lymphoma in extranasal sites: A comparative clinicopathological study according to site and EBV status. Histopathology 44:480, 2004 25. Pfreundschuh M, Trümper L, Kloess M, et al: Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: Results of the NHL-B2 trial of the DSHNHL. Blood 104:634, 2004 26. Isobe K, Uno T, Tamaru J, et al: Extranodal natural killer/T-cell lymphoma, nasal type. Cancer 106:609, 2006 J Oral Maxillofac Surg 68:681-683, 2010 Infiltrating Angiolipoma of a the Oral Cavity: Report of a Case and Literature Review Stylianos Dalambiras, MD, DDS, PhD,* Ioannis Tilaveridis, MD, DDS, PhD,† Savas Iordanidis, MD, DDS, PhD,‡ Thomas Zaraboukas, MD, PhD,§ and Apostolos Epivatianos, DDS, PhD Benign lipomatous tumors are classified into 5 groups: 1) lipoma; 2) variants of lipoma; 3) heterotopic lipo- mas, hamartomatous lesions; 4) infiltrating or dif- fuse neoplastic or non-neoplastic proliferations of mature fat; and 5) hibernoma. 1 Angiolipoma is a variant of lipoma and is distinguished in the nonin- filtrating and infiltrating type. 2 Infiltrating angioli- poma most often occurs in the trunk and extremi- ties 3,4 and is rare in the head and neck region. Some authors 5,6 believe that infiltrating angiolipoma could represent diffuse angiomatosis associated with fat, rather than a neoplasm. Review of the literature revealed only 8 cases of infiltrating angio- lipoma, 2,7-12 of which 3 cases were located in the oral cavity. 8,11,12 We report a case of infiltrating angiolipoma affect- ing the oral cavity and present a review of the litera- ture. A 56-year-old woman was referred to the Depart- ment of Oral and Maxillofacial Surgery in December 2007 for evaluation of a painless swelling on the labial mucosa that had been present for 2 months. The medical and familial histories of the patient were unremarkable. Clinical examination showed a sessile ill-defined swelling, soft and painless on palpation, covered with normal mucosa, measuring 1  1.2 cm, and located in the left upper labial mucosa at the border with the vermilion of the lip (Fig 1). Primary diagnosis for a mucocele led us to perform fine-needle aspiration, which yielded only scattered nondiagnos- tic cells. Subsequently, a tentative diagnosis of soft tissue or salivary gland tumor was made. Under local anesthesia, surgery revealed a 1  1.2  0.5-cm pale yellow mass that infiltrated the underlying muscle fibers, and therefore surgical excision with adequate margins of healthy tissue was performed. One-year follow-up showed no evidence of recurrence. Histological examination showed the lesion to be nonencapsulated and to consist of mature adipocytes and proliferating blood vessels that, in many areas, penetrated between muscle fibers. Some blood ves- sels contained fibrin thrombi (Figs 2, 3). Mitotic fig- ures, lipoblasts, and cellular atypia were not ob- served. Based on the histological findings, a diagnosis of infiltrating angiolipoma was made. Received from University of Thessaloniki, Thessaloniki, Greece. *Assistant Professor, Department of Oral and Maxillofacial Sur- gery, Dental School. †Lecturer, Department of Oral and Maxillofacial Surgery, Dental School. ‡Associate Professor, Department of Oral and Maxillofacial Sur- gery, Dental School. §Associate Professor, Department of Histopathology, Medical School. Associate Professor, Department of Oral Medicine and Oral Pathology, Dental School. Address correspondence and reqrint requests to Dr Epivatianos: Department of Oral Medicine, Oral Pathology, Dental School, Uni- versity of Thessaloniki, Thessaloniki 54124, Greece; e-mail: aepivati@dent.auth.gr © 2010 American Association of Oral and Maxillofacial Surgeons 0278-2391/10/6803-0033$36.00/0 doi:10.1016/j.joms.2009.04.131 DALAMBIRAS ET AL 681