_____________________________________________________________________________________________________ *Corresponding author: E-mail: Robert.malkin@duke.edu; Journal of Advances in Medicine and Medical Research 33(23): 284-291, 2021; Article no.JAMMR.80013 ISSN: 2456-8899 (Past name: British Journal of Medicine and Medical Research, Past ISSN: 2231-0614, NLM ID: 101570965) The Effect of Vaping and Nicotine-containing Liquids to Suppress the Immune System: A Pilot Study Sanjana Anand a , Madeline Wilkerson b and Robert Malkin b* a International Research Institute of North Caroline, United States. b Duke University, United States. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JAMMR/2021/v33i2331212 Editor(s): (1) Dr.Chan-Min Liu, Xuzhou Normal University, China. Reviewers: (1) Steve, USA. (2) Frih Hacene, Badji Mokhtar University, Algeria. Complete Peer review History, details of the editor(s), Reviewers and additional Reviewers are available here: https://www.sdiarticle5.com/review-history/80013 Received 09 October 2021 Accepted 18 December 2021 Published 19 December 2021 ABSTRACT Aims: We present a pilot study to illustrate how the impact of vaping can be quickly and conclusively documented in a large population and appropriate subpopulations. Methods: It has been predicted that with longer duration and higher frequency of vaping, there would be a higher frequency of, a longer duration of, and more severe flu and cold symptoms — indicating a negative impact on the immune system. Studies have linked electronic cigarettes and vaping to respiratory and cardiovascular issues, drastic changes in blood pressure, and the reduced function of tissues and cells in the lungs, but only in small populations, making generalization to the entire population less convincing. A sample of 120, 18–22-year-olds in northern California were asked to complete a 14-question, two-minute, anonymous survey. Those with pre-existing respiratory ailments or a family history of respiratory ailments were excluded from the study along with those who smoke cigarettes or have smoked cigarettes in the past. The survey collected the frequency and time spent vaping and the severity, frequency, and longevity of the flu and cold symptoms. Responses were converted into numerical values and analyzed. Results: Those who vaped more often had more severe flu and cold symptoms (p<0.005). However, no strong trends were present as can be expected from a pilot study. A power analysis Study Protocol