International Journal of Contemporary Pediatrics | March 2020 | Vol 7 | Issue 3 Page 596 International Journal of Contemporary Pediatrics Nayan S et al. Int J Contemp Pediatr. 2020 Mar;7(3):596-601 http://www.ijpediatrics.com pISSN 2349-3283 | eISSN 2349-3291 Original Research Article Third trimester maternal blood and at birth cord blood lipid profile characteristics in pregnant woman with or without fetal growth restriction Swati Nayan 1 , Mohan Meena 1 , Lata Rajoria 1 , Nupur Hooja 1 , Sunil Gothwal 2 *, Andleeb Fatima 1 , B. S. Meena 1 , Ghan Shyam Bairwa 3 , Priyanaka Meena 4 , Rajni Nawal 1 , Megha Sharma 1 INTRODUCTION Maternal nutrition plays a major role in fetal growth and birth outcome. However, the association between maternal nutrition and birth outcome is complex and is influenced by many biologic, socioeconomic, and demographic factors. 1 Maternal nutrition depends on intake of carbohydrates, proteins, lipids and micronutrients. Lipids are one of the macronutrients and transferred to the fetus in form of cholesterol from mother via placenta. 2 Altered lipid levels were found in mothers with intrauterine growth restricted (IUGR)fetus 1 Department of Gynecology and Obstetrics, 2 Department of Pediatrics, SMS Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India 3 Department of Pediatrics, Jaipuria Hospital and RUHS Jaipur, Rajasthan, India 4 Department of Biochemistry, SMS Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India Received: 02 January 2020 Revised: 17 January 2020 Accepted: 30 January 2020 *Correspondence: Dr. Sunil Gothwal, E-mail: dr.sunilgothwal@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: To study the lipid profile of 3rd trimester pregnant women and their cord blood with and without intrauterine growth restriction Design: Observational study, Setting: Department of Obstetrics and Neonatology, in a teaching hospital in North India during February 2013 to August 2014. Methods: Third trimester pregnant women and their neonates. Enrolled 250 women were divided in intrauterine growth restricted and control groups. Outcome Measures: Venous blood Lipid levels of 3rd trimester mothers and their neonate at birth. Results: Women of IUGR group had significantly lowered total cholesterol (TC), triglycerides (TG), high density lipoproteins (HDL) and low density lipoproteins (LDL)210.2 (19.8), 221.6 (36.2),65.4(11.7)and 130.7 (20.8)compared to 251(55.3), 234.7(35.6), 70.8(19.9) and 181.3(16.8) mg/dl control group. The TC, TG and LDL levels in cord blood of IUGR group were 93.6(16.5), 50.4 (6.5) and 51.8(12.6) as compared 106.4(17.7), 30.7(4.4) and 55.9(12.1) mg/dl to control group (p value <0.05). HDL levels were significantly lower 15.8(4.6) in IUGR group as compared to 26.5(5.4) in control group. The LDL: HDL and TC: HDL ratio was significantly higher in IUGR group. Maternal weight, gestational age, urban residence, primi parity, birth weight and APGAR score were lower, while maternal age, parity, smoking, blood pressure, cesarean sections (%) and male sex (%) of baby was higher in IUGR group. Conclusions: Lipid profile of mothers of IUGR fetuses had significantly lowered cholesterol levels and their cord blood had shown atherogenic phenotype. Keywords: Intrauterine growth restriction, Lipid profile, Neonates, Pregnancy, 3 rd trimester pregnancy DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20200685