International Journal of Computational Models and Algorithms in Medicine, 2(2), 23-41, April-June 2011 23 Copyright © 2011, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited. Keywords: Autism Spectrum Disorder, Facial Expression Recognition, Facial Expression Wonderland, Information and Computer Technology, Pervasive Developmental Disorders IntroductIon Autism Spectrum Disorder (ASD) is one of the Pervasive Developmental Disorders (PDDs). Currently, the major cause of ASD is still un- known. ASD is commonly characterized by the lack of social skills, cognition deficits in facial expression recognition and Theory of Mind (ToM), language delay and rigid behaviors the role of Information and computer technology for children with Autism Spectrum disorder and the Facial expression Wonderland (FeW) Rung-Yu Tseng, Georgia Institute of Technology, USA Ellen Yi-Luen, Georgia Institute of Technology, USA AbStrAct Autism Spectrum Disorder (ASD) is one of the Pervasive Developmental Disorders (PDDs). Signifcant defcits in the children with ASD include lack of social communication skills and cognitive dysfunction. This paper reviews and evaluates the infuence of different kinds of Information and Computer Technology (ICT) applications that facilitate intervention and training for children with ASD. This paper also presents a novel design prototype, Facial Expression Wonderland (FEW), to train the children with ASD based on the progres- sive levels of training under a given background context. This prototype is designed to improve the ability of the ASD children in facial expression recognition. (American Psychiatric Association, 1994). In addition, most ASD children have certain ex- tent of mental retardation. Typically, in daily life these children lack social communication skills to interact with others and are often seen as social outcasts. For instance, ASD children, like most children, might not have eye contact with others during an inter-person conversa- tion. Others could misinterpret this manner as rude behavior when meeting these children for the first time. Additionally, they are highly DOI: 10.4018/jcmam.2011040102