This article is protected by copyright. All rights reserved REVIEW ARTICLE Macrophage plasticity, polarization and function in health and disease † Running title: Macrophages in Health and Disease Abbas Shapouri Moghaddam 1 , Saeed Mohammadian 2 , Hossein Vazini 3 , Mahdi Taghadosi 4 , Seyed- Alireza Esmaeili 2 , Fatemeh Mardani 2 , Bita Seifi 5 , Asadollah Mohammadi 6 , Jalil Tavakol Afshari 1 , Amirhossein Sahebkar 7,8,9 * 1. Department of Immunology, BuAli Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 2. Student Research Committee, Immunology Research Center, BuAli Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 3. Nursing Department, Basic Sciences Faculty, Hamedan Branch, Islamic Azad University, Hamedan, Iran. 4. Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. 5. Department of Anatomy, Islamic Azad University, Mashhad branch, Iran. 6. Inflammation and Inflammatory Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 7. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. 8. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 9. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. *Corresponding author: Amirhossein Sahebkar, PharmD, PhD, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, P.O. Box: 91779-48564, Iran. Tel: 985118002288; Fax: 985118002287; E-mail: sahebkara@mums.ac.ir; amir_saheb2000@yahoo.com † This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: [10.1002/jcp.26429] Received 10 September 2017; Revised 19 December 2017; Accepted 5 January 2018 Journal of Cellular Physiology This article is protected by copyright. All rights reserved DOI 10.1002/jcp.26429