Arch Bronconeumol. 2016;52(9):470–476 www.archbronconeumol.org Original Article Patient Outcome After COPD Exacerbations Requiring Non-invasive Ventilation During Hospitalization  Fatma Tokgoz Akyil, a,* Hakan Gunen, a Meltem Agca, a Sinem Gungor, a Murat Yalcinsoy, a Pakize Sucu, a Mustafa Akyil, b Tulin Sevim a a Department of Chest Diseases, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Estambul, Turkey b Department of Thoracic Surgery, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Estambul, Turkey a r t i c l e i n f o Article history: Received 31 October 2015 Accepted 8 January 2016 Available online 6 April 2016 Keywords: Arterial blood gas Chronic obstructive pulmonary disease Noninvasive ventilation Respiratory failure a b s t r a c t Introduction: Noninvasive ventilation (NIV) during hospitalization for acute hypercapnic exacerbations of chronic obstructive pulmonary disease (COPD) has been shown to be effective, but data on the prognosis of such patients is limited. The aim of this study was to investigate in-hospital and long-term outcome in patients with COPD exacerbations requiring NIV treatment during hospitalization. Methods: Between 2011 and 2013, hospitalized subjects with hypercapnic COPD exacerbations were included in this retrospective single-center cohort study. Subjects’ clinical and laboratory data and sur- vival status after a median of 27 months were recorded. The predictive factors of in-hospital and long-term mortality were analyzed. Results: A total of 574 patients (357 men, mean age 68±11 years) were recorded. During hospitalization, 24 (4.1%) patients died. In-hospital mortality was negatively affected by lower baseline values of hema- tocrit, albumin, and pH, and by higher baseline leucocytes and higher 24 h PaCO 2 . Median survival of the cohort was 27 months. Mortality at 3 and 6 months, and 1 year were 14.5%, 19.5%, and 30%, respec- tively. In the univariate analysis, reduction in long-term survival was found to be related to older age, higher Charlson score, lower baseline levels of hematocrit and albumin, and lower pH level after 24 h. In the multivariate analysis, older age and lower albumin were identified as the strongest predictors of mortality. Conclusion: Life expectancy after a COPD exacerbation requiring NIV treatment is short. Baseline blood counts and day 2 arterial blood gases levels may predict in-hospital mortality. The strongest indicators of poorer long-term outcome were advanced age and lower albumin. Such patients may need closer follow-up. © 2016 SEPAR. Published by Elsevier Espa ˜ na, S.L.U. All rights reserved. Supervivencia en exacerbaciones de la EPOC que requirieron ventilación no invasiva en planta Palabras clave: Gasometría arterial Enfermedad pulmonar obstructiva crónica Ventilación no invasiva Insuficiencia respiratoria r e s u m e n Introducción: La introducción de la ventilación no invasiva (VNI) durante las exacerbaciones agudas hiper- cápnicas de la enfermedad pulmonar obstructiva crónica (EPOC) en plantas de hospitalización general ha demostrado ser eficaz, pero hay escasos datos sobre el pronóstico de estos pacientes. El objetivo de este estudio fue investigar la evolución intrahospitalaria y a largo plazo de pacientes con exacerbaciones de la EPOC que requirieron terapia VNI durante su ingreso en plantas de hospitalización general.  Please cite this article as: Akyil FT, Gunen H, Agca M, Gungor S, Yalcinsoy M, Sucu P, et al. Supervivencia en exacerbaciones de la EPOC que requirieron ventilación no invasiva en planta. Arch Bronconeumol. 2016;52:470–476. * Corresponding author. E-mail address: fatmatokgoz86@gmail.com (F.T. Akyil). 1579-2129/© 2016 SEPAR. Published by Elsevier Espa ˜ na, S.L.U. All rights reserved.