JPET #118000 1 Pre-clinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition and cognitive efficacy. Tadanobu Utsuki, Nao Uchimura, Mitsuru Irikura, Hiroshi Moriuchi, Harold W. Holloway, Qian-sheng Yu, Edward L. Spangler, Jacek Mamczarz, Donald K. Ingram, Tetsumi Irie, Nigel H. Greig. Drug Design and Development Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA (T.U., H.W.H, Q-S.Y., N.H.G), Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA (T.U., D.K.I.), Division of Clinical Chemistry & Informatics, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan (N.U., M.I., H.M., T.I.), Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD (E.L.S., J.M., D.K.I.) JPET Fast Forward. Published on January 25, 2007 as DOI:10.1124/jpet.106.118000 Copyright 2007 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on January 25, 2007 as DOI: 10.1124/jpet.106.118000 at ASPET Journals on December 10, 2021 jpet.aspetjournals.org Downloaded from