ORIGINAL ARTICLE J of Evidence Based Med & Hlthcare, pISSN- 2349-2562, eISSN- 2349-2570/ Vol. 1/Issue 11/Nov 17, 2014 Page 1387 COLORECTAL CARCINOMA IN WESTERN RAJASTHAN: A COMPREHENSIVE STUDY AND MANAGEMENT OF 245 CASES Ram Ratan Yadav 1 , Pankaj Saxena 2 , P. K. Bhatnagar 3 , Rita Saxena 4 , Shivcharan Navariya 5 , Pankaj Porwal 6 HOW TO CITE THIS ARTICLE: Ram Ratan Yadav, Pankaj Saxena, P. K. Bhatnagar, Rita Saxena, Shivcharan Navariya, Pankaj Porwal. “Colorectal Carcinoma in Western Rajasthan: A Comprehensive Study and Management of 245 Cases”. Journal of Evidence based Medicine and Healthcare; Volume 1, Issue 11, November 17, 2014; Page: 1387-1396. ABSTRACT: Colorectal Carcinoma is most common malignancy in GIT, 3 rd most common after lung and Breast. (1) These patients commonly present with altered bowel habits, bleeding PR, pain, lump abdomen. (2) In the present study 245 cases from west Rajasthan over a period of 26 months were studied for Age, Sex, Clinical presentation, Investigation, Subsequent management, Complication and Follow-up. Peak incidence of disease is in 6 th decade of life with M/F ratio 1.8:1. Most common presentation was altered bowel habits. Most patients presented in advanced Duke’s C with moderately differentiated Adenocarcinoma. CEA levels were <5 ng/mL. Preoperative surgical feasibility for curative resection was present in 64.44% pts. CEA level is good indicator to monitor recurrence of the disease. Surgery is the mainstay of the treatment. There is a role of adjuvant chemotherapy in all cases of colorectal cancer. Follow-up study is mandatory in all patients for early management of recurrent disease. KEYWORDS: COLORECTAL CARCINOMAGIT MALIGNANCYCOLON CARCINOMAADENOCARCI- NOMAOCCULT BLOODCOLONOSCOPYSIGMOIDOSCOPY. INTRODUCTION: Colorectal cancer (CRC) is one of the most common forms of gastrointestinal malignancies in the world. (3) Compared to the Western world, the incidence rates of colorectal cancer are low in India; for colon cancer they vary from 0.7 to 3.7/100,000 among men and 0.4 to 3/100,000 among women, and for rectal cancer from 1.6 to 5.5/100,000 among men and 0 to 2.8/100,000 among women. (4) The vast majority of patients with CRC are above the age of 65 years. (5) CRC occurring before age of forty years accounts for less than 10% of the total CRC. It has been reported that CRC in the Asia-Pacific region and Africa occur a decade or more earlier compared to the USA. The most common location of CRC is the left side of the colon including the rectum. (6) However, reports from the West suggest that the tumor location of CRC is moving proximal to the splenic flexure. Prevention and early detection are key factors in controlling and curing colorectal cancer. (7) When the cancer is found early, initial treatment can often lead to an excellent outcome The extent to which a cancer penetrates the various tissue layers determines the stage of the disease. (8) Most colorectal cancers grow slowly over a period of several years, often beginning as small benign growths called polyps. Removing these polyps early, before they become malignant, is an effective means of preventing colorectal cancer. (9)