Accepted Manuscript H 2 O-Mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3- tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation Pankaj Sharma, Kishna Ram Senwar, Manish Kumar Jeengar, T.Srinivasa Reddy, V.G.M. Naidu, Ahmed Kamal, Nagula Shankaraiah, Dr. PII: S0223-5234(15)30269-5 DOI: 10.1016/j.ejmech.2015.09.025 Reference: EJMECH 8122 To appear in: European Journal of Medicinal Chemistry Received Date: 20 July 2015 Revised Date: 14 September 2015 Accepted Date: 15 September 2015 Please cite this article as: P. Sharma, K.R. Senwar, M.K. Jeengar, T.S. Reddy, V.G.M. Naidu, A. Kamal, N. Shankaraiah, H 2 O-Mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3- tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation, European Journal of Medicinal Chemistry (2015), doi: 10.1016/j.ejmech.2015.09.025. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.