Cardiologia Croatica 2015;10(9-10):207. 4 th Dubrovnik Cardiology Highlights an ESC Update Programme in Cardiology Goal: The clinical value of cardiac biomarkers (such as brain natriuretic peptide (BNP) or troponin T) in heart transplant (HTx) recipients is not completely defned. Despite multiple published studies on the association between cardiac biomarkers and survival or acute allograft rejection, there is insuf- fcient evidence to recommend them in everyday clinical practice. 1,2 We sought to explore survival of patients after HTx in relation to NTpro-BNP and high sensitive TnT (hs-TnT) values throughout the 1st post-HTx year in our center. Patients and Methods: In this retrospective observational study we included 74 consecutive HTx recipients (53 male, me- dian follow-up 24 months) in whom we obtained NTpro-BNP (pg/mL) and hs-TnT (pg/L) values at 1, 6 and 12 months after HTx. For each time point, we used the median of measurements as a cut-off value for further analysis. Survival rates were analysed by the Kaplan-Meier method (log rank test), followed by the uni- variate Cox hazard regression analysis. Results: Cut-off median values for respective measurements at specifc time points were as follows: NTpro-BNP 1967.5, 418.7 and 366.8 pg/mL; hs-TnT 90, 18.5 and 16 pg/L at 1, 6 and 12 months after HTx, respectively. The patients with lower hs-TnT values at 12-months after HTx had signifcantly better survival rates (p = 0.048) (Figure 1), with a HR of 1.014 (95% CI 1.003-1.024 p = 0.01). Although NTpro-BNP and hs-TnT values at the earlier time points showed a trend towards better survival in patients with lower biomarker values, statistical signifcance was not observed. ConClusion: The results of our study suggest the importance of biomarker measurements (particularly hs-TnT), even in the later post-transplant period. Larger study groups might enforce its role in detecting individuals at higher risk for worse outcomes. Dora Fabijanović*, Ivo Planinc, Jana Ljubas Maček, Boško Skorić, Željko Baričević, Hrvoje Jurin, Jure Samardžić, Hrvoje Gašparović, Maja Čikeš, Davor Miličić University of Zagreb School of Medicine, University Hos- pital Centre Zagreb, Zagreb, Croatia KeYWoRds: heart transplantation, high sensitive troponin, brain natriuretic peptide. Citation: Cardiol Croat. 2015;10(9-10):207. | doi: http://dx.doi.org/10.15836/ccar.2015.207 *addRess foR CoRResPondenCe: Dora Fabijanović, Klinički bolnički centar Zagreb, Kišpatićeva 12, HR-10000 Zagreb, Croatia. / Phone: +385-98-9387273 / E-mail: dora.fabijanovic@gmail.com oRCid: Dora Fabijanović, http://orcid.org/0000-0003-2633-3439 • Ivo Planinc, http://orcid.org/0000-0003-0561-6704 Jana Ljubas Maček, http://orcid.org/0000-0001-7171-2206 • Boško Skorić, http://orcid.org/0000-0001-5979-2346 Željko Baričević, http://orcid.org/0000-0002-5420-2324 • Hrvoje Jurin, http://orcid.org/0000-0002-2599-553X Jure Samardžić, http://orcid.org/0000-0002-9346-6402 • Hrvoje Gašparović, http://orcid.org/0000-0002-2492-3702 Maja Čikeš, http://orcid.org/0000-0002-4772-5549 • Davor Miličić, http://orcid.org/0000-0001-9101-1570 the relevance of biomarkers 1 year after heart transplantation: is there increased predictive value of high sensitive troponin? liteRatuRe 1. Erbel C, Taskin R, Doesch A, Dengler TJ, Wangler S, Akhavanpoor M, et al. High-sensitive Troponin T measurements early after heart transplanta- tion predict short- and long-term survival. Transpl Int. 2013;26(3):267-72. doi: http://dx.doi.org/10.1111/tri.12024 2. Battes LC, Caliskan K, Rizopoulos D, Constantinescu AA, Robertus JL, Akkerhuis M, et al. Repeated measurements of NT-pro-B-type natri- uretic peptide, troponin T or C-reactive protein do not predict future allograft rejection in heart transplant recipients. Transplantation. 2015;99(3):580-5. doi: http://dx.doi.org/10.1097/TP.0000000000000378 Extended Abstract ADVANCED HEART FAILURE: HEART TRANSPLANTATION & MCS ReceIved: September 14, 2015 AccePted: September 17, 2015 fiGuRe 1. Cumulative survival based on hs- tnt levels 12 mont- hs post-htx.