ORIGINAL RESEARCH PAPER COMPARATIVE ANALYSIS OF OSSEOINTEGRATION WITH OR WITHOUT PRF (PLATELET RICH FIBRIN) IN ORAL IMPLANTOLOGY- A RANDOMIZED PROSPECTIVE CLINICAL STUDY Dr. Sweta Parna Deb* Consultant Oral and Maxillofacial Surgery, Guhwati, Assam, India.*Corresponding Author Dr. Rakesh Ranjan Consultant Oral and Maxillofacial Surgery, Patna, Bihar. Dr. Bineet Kumar Postgraduate student, Department of Prosthodontics & Crown & Bridge, Vananchal dental college& hospital, Gharwa, Jharkhand. Dr. Akash Raj Sharma Post graduate student, Department of Prosthodontics & crown and bridge, Institute of Dental Studies & Technologies, Modinagar, Uttar Pradesh, India. Dr. Md Kashif Noorani Senior Lecturer, Department of Prosthodontics & crown and bridged. Dr. B. R. Ambedkar institute of dental sciences and Hospital. Patna, Bihar. Dr. Ayusha Kumari Postgraduate student, Department of Peridontology, Vananchal dental college& hospital, Gharwa, Jharkhand. INTRODUCTION Dental implants have become a popular treatment modality in recent times, with predictable long-term results for rehabilitation of partially or totally edentulous patients. Being next to natural teeth, dental implants have gained a great fame both amongst the clinicians as well as patients in a very short time. Once osseointegrated they have got better stability and life as compared to removable or xed dentures. Achieving good osseointegration plays a major role in the long term stability of the implants; therefore these days' new methods are being used to improve the quality of osseointegration. Inspite of using correct surgical protocol and procedure there are still quite a few [1,2] instances of implant failure in oral implantology. Surgeons are constantly looking for a “breakthrough” that can act as a catalyst to the healing process to maximize predictability as well as the volume of regenerated bone. Platelet Rich Fibrin (PRF) is a second generation platelet concentrate which is a new biotechnology, it has been suggested to be of great use in implant dentistry as it can speed up and enhance the quality of osseointegration. Different studies show that it [3,4] enhances the healing of bone. So our study focuses on comparing the quality of osseointegration using platelet rich brin in dental implant placement over conventional implant placement. MATERIALS & METHOD st st A prospective research was designed with a follow up of 1 week, 1 rd and 3 month postoperatively. All the patients who reported to the outpatient department for replacement of missing teeth or for extraction of a non-restorable tooth along with its replacement were taken for this study according to the inclusion and exclusion criteria. INCLUSION CRITERIA: 1. All patients above the age group of 16 years; 2. Patients who need replacement of single or multiple teeth in the anterior or posterior region of the maxilla and mandible; 3. Presence of non-restorable teeth due to trauma, caries, root resorption, root fracture, endodontic or periodontal failure. Exclusion criteria: 1. Medically compromised patients 2. Patients having craniofacial syndromes. Sample Size 40 dental implants were placed in total. 20 implants each placed along with PRF (Platelet rich brin) [Group A] and without using PRF [Group B]. Patients were followed-up immediate post operatively, at st st rd 1 week, 1 month, and 3 month. During follow-up period, the patients were assessed radiologically using CBCT by comparing their quality of osseointegration (in gray values) and amount of crestal bone loss at rd the end of 3 month, and clinically for pain, implant exposure, infection, mobility and wound dehiscence . Procedure For Group A [Fig. 3-15] blood was drawn from the patient and is taken without anticoagulant in 10-mL glass coated plastic tubes that were immediately centrifuged at 3000 rpm for 10 minutes. After processing, 2 distinct samples will be collected [Fig. 1]. The supernatant layer represents platelet poor plasma (PPP) or acellular plasma, and PRF clot with an exudate trapped in the brin meshes [Fig. 2]. In order to collect it, we leave the PRF clots in a sterile metal cup for 10 minutes approximately to let them slowly release the serum contained therein [Fig. 8]. PRF is then obtained in the form of a membrane by squeezing [4] out the uids from the brin clot. This is applied to the osteotomy site before placing the implant [Fig. 10]. Then the implant was placed and nal closure was done. Post-operative instructions were given to the patient. The implants were placed similarly in Group B [Fig. 16-25] but without using PRF. The patients were recalled after one week for suture removal. This was followed by a 3 month waiting period. After which CBCT was done to evaluate the quality of osseointegration measured in grayvalue using the Galileos Implant Software- Sirona. RESULTS: BONE DENSITY IN GRAY VALUE (post operative CBCT after 3 months) INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH Dental Science International Journal of Scientific Research 29 Volume - 9 | Issue - 11 | November - 2020 | PRINT ISSN No. 2277 - 8179 | DOI : 10.36106/ijsr ABSTRACT INTRODUCTION:Dental rehabilitation of partially or totally edentulous patients with dental implants has become a popular treatment modality with reliable long-term results. These days' new methods are being used to improve the quality of osseointegration. Platelet Rich Fibrin (PRF) is a second generation platelet concentrate which is a new biotechnology, it has been suggested to be of great use in implant dentistry as it can enhance the quality of osseointegration. Various studies show that it improves healing of both hard as well as soft tissues. Aim :To compare the quality of osseointegration using platelet rich brin over conventional implant placement. Materials & Methods : 40 dental implants were placed in total for this study. 20 implants each were placed with PRF (Goup A) and without PRF (Group B) in the osteotomy site. After three months CBCT was done to evaluate and compare the quality of osseointegration between the 2 groups measured in gray value using the Galileos Implant Software- Sirona. Result: Mean values obtained were ≈1928 in group A (with PRF) and ≈1734.6 in group B (without PRF). Independent Samples T-Test showed a signicant p-value of 0.013 ( p-value>0.05). Conclusion: Results from our study show that PRF can play a promising role in the quality of osseointegration when used as a biomaterial in oral implantology. Our study provides a basis for future research with larger sample size and longer follow-ups to elucidate this outcome further. KEYWORDS Platelet Rich Fibrin, Implant, Osseointegration, Multiple teeth.