Review Artcle Journal of Communicable Diseases (P-ISSN: 0019-5138 & E-ISSN: 2581-351X) Copyright (c) 2020: Advanced Research Publicatons Journal of Communicable Diseases Volume 52, Issue 4 - 2020, Pg. No. 81-87 Peer Reviewed & Open Access Journal Corresponding Author: Alisha Rewari, Faculty of Dental Sciences, SGT University, Gurugram, Haryana, India. E-mail Id: alisha.rewari@gmail.com Orcid Id: htps://orcid.org/0000-0002-3066-1681 How to cite this artcle: Rewari A, Sanan R, Dabas N, Phogat S, Singh D. COVID-19 in Geriatric Age Group - A Review. J Commun Dis 2020; 52(4): 81-87. Date of Submission: 2020-11-09 Date of Acceptance: 2020-12-20 I N F O A B S T R A C T COVID-19 in Geriatric Age Group - A Review Alisha Rewari 1 , Reshu Sanan 2 , Nupur Dabas 3 , Shefali Phogat 4 , Diksha Singh 5 1,5 Post Graduate Student, 2,4 Associate Professors, 3 Professor, Faculty of Dental Sciences, SGT University, Gurugram, Haryana, India. DOI: htps://doi.org/10.24321/0019.5138.202045 Coronavirus pandemic is an unprecedented global crisis that has afected the entre mankind. The elderlies are a specifc cluster of high-risk patents for developing COVID-19 infecton with rapid clinical deterioraton. Frailty and comorbid conditons in the geriatric age group may be associated with mortality, considering the diversity of results in the existng literature. The present document has been drafed to review the available literature and evidences on this infecton in geriatric age group which is partcularly vulnerable to this disease and its fatal manifestatons. Keywords: Geriatric Age, COVID-19, Comorbidity, Therapeutcs, ACE2 Receptor, Frailty Introduction Coronaviruses (CoVs) represent a heterogeneous cluster of positve stranded RNA viruses, that target the human respiratory system. 1 They belong to the family of Coronaviridae, the alpha and beta-coronavirus being the genera of human interest. Other outbreaks of coronavirus that have been a major threat to public health in the past include the severe acute respiratory syndrome (SARS)-CoV and the Middle East respiratory syndrome (MERS)-CoV. 2 In late December 2019, a group of patents with an inital diagnosis of pneumonia of unknown etology were admited to the hospital in Wuhan, Hubei, China. Epidemiologically, these patents were linked to a seafood market in Wuhan. 2,3 Research identfed the cause of infecton being a novel coronavirus labelled as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease was referred to as COVID-19 by WHO on Feb 11, 2020. 4 As of September 2, 2020, the World Health Organizaton has confrmed 25,541,380 cases of COVID-19 in 216 countries worldwide. India has reported 3,794,314 confrmed cases of COVID-19 and 66,678 deaths so far whereas 2,920,122 infected patents have been recovered. The rate of mortality of COVID-19 increases with advancing age while children are observed to be less susceptble to death. 5,6 Italy and Spain are the world’s two worst hit countries by the COVID-19 pandemic. The two Mediterranean countries have large elderly populatons, highly social citzens and densely populated cites. Spain and Italy’s failure to recognize the magnitude of the pandemic led to around 40% of total global COVID-19 deaths in April 2020. Infecton with this virus causes diverse clinical manifestatons which include respiratory symptoms, from the common cold to severe pneumonia with an Acute Respiratory Distress Syndrome (ARDS), septc shock, mult organ failure and death. 7 The present document has been drafed to review the available literature and evidences on this infecton in geriatric age group which is partcularly vulnerable to this disease and its fatal manifestatons. Pathogenesis of Covid-19 SARS-CoV-2 is a single, positive stranded RNA virus, enveloped in a lipid bilayer. The lipid bilayer fuses with the host cell membrane to release RNA into the cytoplasm