Research Article Chronic Patients’ Activation and Its Association with Stress, Anxiety, Depression, and Quality of Life: A Survey in Southeast Iran Mohammad Ali Zakeri , 1,2 Mahlagha Dehghan , 3 Fatemeh Ghaedi-Heidari , 4 Maryam Zakeri , 5 and Gholamreza Bazmandegan 6,7 1 Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 2 Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 3 Nursing Research Center, Kerman University of Medical Sciences, Kerman, Iran 4 Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran 5 Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 6 Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 7 Department of Family Medicine, Ali-Ibn Abi-Talib Hospital, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Correspondence should be addressed to Gholamreza Bazmandegan; bkhrbster@gmail.com Received 6 November 2020; Revised 6 March 2021; Accepted 18 March 2021; Published 26 March 2021 Academic Editor: Yeong Shiong Chiew Copyright © 2021 Mohammad Ali Zakeri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A better perception of the factors associated with patient activation, as a way to improve self-management, is the most important step in planning patient-centered education for chronic disease management. Therefore, the present study is aimed at investigating the relationship between activation, stress, anxiety, depression, and quality of life (QOL) in patients with chronic diseases. This correlational study was performed on 293 chronic patients admitted to coronary care units (CCUs) in one of the hospitals in Rafsanjan. The Patient Activation Measure (PAM), Quality of Life-BREF (WHOQOL-BREF), and Depression, Anxiety, and Stress Scale-21 Items (DASS-21) were used to collect data. The data were then analyzed using SPSS 22. A significant positive correlation was observed between general QOL and PAM (P <0:001). In addition, a significant negative correlation was found between PAM, stress (P =0:032), and depression (P =0:025). The results of multivariate linear regression indicated that only physical and psychological subscales of QOL significantly predicted PAM (B =0:24; 95% confidence interval; P value < 0.05). Owing to the fact that some subscales of QOL have a determinant role in the PAM of chronic patients, healthcare providers are recommended to plan and implement the necessary interventions to improve the QOL and the health outcomes of chronic patients. 1. Introduction The silent pandemic of chronic diseases, one of the biggest public health challenges worldwide, is gradually spreading to all countries [1]. Chronic diseases have a high mortality rate and impose a heavy burden on healthcare systems [2]. According to the Institute of Health Metrics and Evalua- tion (IHME), chronic diseases accounted for 72% of the causes of death in 2016 [1]. According to the World Health Organization (WHO), chronic diseases caused 73 percent of deaths and 60% of the global burden of disease in 2020. In addition, 79% of these deaths will occur in developing countries [3]. The most common chronic dis- eases, including cardiovascular disease, cancer, chronic obstructive pulmonary disease (COPD), and type 2 diabe- tes have common and preventable risk factors such as hypertension, weight gain, and high-risk behaviors such as poor nutrition, sedentary lifestyle, and smoking [4]. Hindawi BioMed Research International Volume 2021, Article ID 6614566, 8 pages https://doi.org/10.1155/2021/6614566