J Appl Biol Chem (2017) 60(2), 161-171 https://doi.org/10.3839/jabc.2017.027 Online ISSN 2234-7941 Print ISSN 1976-0442 Article: Food Science/Microbiology Comparison of proximate compositions, antioxidant, and antiproliferative activities between blueberry and Sageretia thea (Osbeck) M.C.Johnst fruit produced in Jeju Island Gyeong-A Ko 1 · So Yae Koh 2 · Ji-yeon Ryu 3 · Somi Kim Cho 1,2,3,4 제주산 블루베리와 상동열매의 일반성분, 항산화 및 항증식 활성 비교 고경아 1 · 고소예 2 · 류지연 3 · 김소미 1,2,3,4 Received: 5 May 2017 / Accepted: 5 June 2017 / Published Online: 30 June 2017 © The Korean Society for Applied Biological Chemistry 2017 Abstract This study was aimed to evaluate and compare the proximate composition, antioxidant and antiproliferative activities of Sageretia thea (Osbeck) M.C.Johnst (S. thea) fruit and blueberry. The calorific value, crude protein, crude fat, crude ash, and carbohydrate were higher in S. thea fruit than in blueberry. S. thea fruit and blueberry have different profile of free sugars, in which amounts of fructose, glucose, and maltose were much higher in S. thea fruit than in blueberry. The methanol extracts of S. thea fruit contain higher amounts of total polyphenol and anthocyanin compared to those of blueberry extracts. In additions, 2,2-diphenyl-1-picrylhydrazyl (DPPH), alkyl, and 2,2'-azino- bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging activities are greater in S. thea fruit extracts. Ethyl acetate fractions and n-butanol fractions of S. thea fruit and blueberry show the most potent scavenging activity in DPPH-, alkyl-, and ABTS-radical scavenging assay. The ethyl acetate fractions of S. thea fruit and blueberry are the richest fraction in polyphenol contents while the n-butanol fractions of those are the highest fraction in anthocyanin contents. Furthermore, both S. thea fruit and blueberry extracts protect human dermal fibroblast cells against a H 2 O 2 -induced oxidative stress. The antiproliferative activities of n-hexane and chloroform fraction from S. thea fruit and blueberry were observed in AGS human gastric cancer and MDA-MB-231 human breast cancer cells. Therefore, our results suggest for the first time that the antioxidant and antiproliferative activities of S. thea fruit is comparable to that of blueberry and the nutritional value of the former is even superior to that of the latter. Keywords Antioxidant · Antiproliferative · Blueberry · Proximate compositions · Sageretia thea (Osbeck) M.C.Johnst 서 론 최근 들어 경제발전과 생활수준의 향상에 따라 건강한 삶을 지 향하는 식 문화가 확대되고 있다. 식품 소재들에 의한 질병예 방, 건강증진 효능 및 노화방지에 대한 효능이 밝혀지면서, 생 명현상유지뿐만 아니라 생리활성 측면에서 식품에 대한 관심이 증대되고 있다(Cho 등, 2010; Chung 2015). 베리류는 작은 열매가 모여 하나의 과실 형태를 유지하는 장 과류를 총칭하는 것으로, 기능성 식품에 대한 관심이 높아짐에 Somi Kim Cho () E-mail: phd.kim.somi@gmail.com; somikim@jejunu.ac.kr Faculty of Biotechnology, College of Applied Life Sciences, SARI, Jeju National University, Jeju 63243, Republic of Korea Faculty of Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Republic of Korea School of Biomaterials Sciences and Technology, College of Applied Life Sciences, SARI, Jeju National University, Jeju 63243, Republic of Korea Subtropical Tropical Organism Gene Bank, Jeju National University, Jeju 63243, Republic of Korea This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.