SP566 THE RELATIONSHIP BETWEEN CORONARY ARTERY CALCIUM SCORES AND LEFT ATRIUM SIZE IN HEMODIALYSIS PATIENTS _ Ismail Baloglu 1 , Kultigin Turkmen 1 , H. Zeki Tonbul 1 , N. Yılmaz Selc ¸uk 1 1 Nephrology Necmettin Erbakan University Konya Turkey INTRODUCTION AND AIMS: Cardiovascular disease (CVD) is 10-20 times higher in patients with end stage renal disease (ESRD) when compared with general population. The coronary artery calcification score (CACS) in uremic patients receiving hemodialysis reflects the severity of atherosclerotic vascular disease and predicts the cardiovascular events. Left atrial (LA) size has a prognostic importance in general population. We aimed to investigate the relationship between LA size and CACS in hemodialysis patients. METHODS: This was a cross-sectional study involving 32 ESRD patients (16 females, 16 males; mean age, 52.4614.1 years) receiving HD for 6 months. CACS was per- formed by a 16-MDCT scanner and calculated by Agatston score. Patients were divided into two subgroups according to median value (group 1; CACS  45.85, n=16 and group 2; CACS> 45.85, n=16). Appropriate statistical analyses were applied. RESULTS: Mean CACS value of 32 hemodialysis patients was 245.56373.9. Baseline characteristics of groups were shown in table 1. LA were significantly higher in patients with CACS>45.85 (group 2) than in patients with CACS45.85 (group 1). In the bivariate correlation analysis, total CACS was positively correlated with left atrium size and age (r=0.47, p=0.006; r=0.43 p=0.014, respectively). LA size was positively correlated with diastolic blood pressure (r=0.42 p=0.016) and negatively correlated with ejection fraction (r=-0.42 p=0.016). The clinical parameters of BMI, duration of dialysis, blood pressure, ejection fraction, serum levels of calcium, phosphorus, uric acid, albumin, CRP, triglyceride, cholesterol, hemoglobin and ferritin were not associated with total CACS. CONCLUSIONS: We found a relationship between the CACS and LA size measured by echocardiography in hemodialysis patients. Therefore; echocardiography, which is cheaper and non-invasive than tomographic examinations, might be considered for the risk stratification of coronary artery disease in hemodialysis patients. SP567 THE EFFECTS OF INTRADIALYTIC EXERCISE PLUS MUSIC ON ANXIETY Spyridon Vrakas 2 , Dimitra Mameletzi 2 , Theodoros Samaras 3 , Vassilios Liakopoulos 1 , Evangelia Kouidi 2 , Asterios Deligiannis 2 1 A’ Internal Medicine Clinic-Renal Unit Aristotle University of Thessaloniki Thessaloniki Greece, 2 Department of Physical Education and Sports Sciences Aristotle University of Thessaloniki Thessaloniki Greece and 3 Department of Physics Aristotle University of Thessaloniki Thessaloniki Greece INTRODUCTION AND AIMS: Hemodialysis (HD) patients experience high levels of anxiety, especially during their dialysis treatment, affecting their quality of life negatively. Studies have shown that both exercise training and listening of music can reduce stress in diseased individuals. In our previous study, a 6-month combination of intradialytic exercise and music was found to improve the cardiac autonomic disturbances significantly. However, it remains unknown whether a short-term com- bined intervention can effectively modify the anxiety levels in HD patients. Therefore, we studied the effects of an intradialytic exercise program, accompanied with music of preference on the levels of anxiety in HD patients. METHODS: Thirty HD patients free of any other systemic disease were randomly assigned into two equal groups: The Exercise-Music Group (aged 47.1615.2 years) completed a 12-week intradialytic exercise program with stationary bicycles and strengthening exercises (3/weekly, for 60 min), while listening to music of their prefer- ence and the Control Group received no intervention. The dialysis prescription, medi- cations and the level of anemia remained constant during the study. At baseline and the end of the study, the exercise tolerance was evaluated by the six-minute walking test (6MWT) and the level of anxiety by the State-Trait Anxiety Inventory (Spielberger et al, 1970) and the skin conductance response (assessed by the Cooking Hacks’ company sensors platform). RESULTS: At baseline, there was no significant difference in either the exercise tolerance or the level of anxiety between the two groups. After training, although the distance walked in the 6MWT increased by 11.8% (p<0.05), the levels of acute anxiety (STAI) and permanent stress (TRAIT) showed no statistically significant difference. Correspondingly, the same was noted when the skin conductance response was measured. In the Control group none of the above variables altered significantly over time. At the end of the 12-week study, there was no statistically significant difference in the level of anxiety between the two groups, although the exercised patients showed an improving trend. CONCLUSIONS: The results of the present study demonstrated that a short-term intradialytic exercise training program accompanied with music of the patients’ prefer- ence is not effective enough for the management of anxiety in HD patients. Thus, either longer intervention period or adding an outpatient exercise-music program may aid in managing anxiety in HD patients. SP568 DETERMINANTS OF ORTHOSTATIC HYPOTENSION IN DIALYSIS PATIENTS Biain Maria Elena 2 , Maximo Schiavone 4 , Carlos Castellaro 1 , Mauro Magenta, Gaston Fernandez Candia 4 , Carlos Calegari, Carlos Diaz, Fernando Speranzoni 1 , Juan Montagnana 1 , Sergio Gonzalez 3 , Felipe Inserra 4 , Gustavo Laham 1 Hypertension Unit Cemic Buenos Aires Argentina, 2 Nephrology Department CEMIC Buenos Aires Argentina, 3 Neuvascular Laboratory, Cardiology Department Hospital Churruca Buenos Aires Argentina and 4 Facultad de Ciencias Biomedicas Universidad Austral Derqui Argentina INTRODUCTION AND AIMS: Objectives: 1) Analyze the prevalence of orthostatic hypotension in patients on dialysis. 2) To establish if orthostatic hypotension is associated with specific hemodynamic changes in supine position and standing. 3) Determine independent predictors of orthostatic hypotension. METHODS: Within a cardiovascular evaluation program for patients with end state renal disease, PRECADIA Collaborative group (PRograma de Evaluacion de salud CArdiovascular de pacientes en DIAlisis). We evaluated 68 patients attended the interdialysis day.BP (Microlife) and hemodynamics was determined with impedance cardiography in supine position and after the third minute of standing. Following variables were analyzed: Systolic blood pressure (SBP), Diastolic blood pressure (DBP), heart rate (HR), stroke volume (SV), systemic vascular resistance index (SVRI) and thoracic fluid content (TFC). Patients were classified into 2 groups according to the presence of Hypotension (HIPOT) or not (EST) of orthostatic hypotension defined as a Nephrology Dialysis Transplantation Abstracts doi:10.1093/ndt/gfx152 | iii325 Downloaded from https://academic.oup.com/ndt/article-abstract/32/suppl_3/iii325/3853506 by guest on 10 June 2020