Submit Manuscript | http://medcraveonline.com Introduction Pemphigus vulgaris , bullous pemphigoid and other bullous disorders may have eye involvement in various range of severity. Patients of pemphigus vulgaris have skin and mucous membrane involvement. Acantholysis is present in suprabasilar layer of epithelium i.e. intraepithelial. On Biopsy, IgG can be confrmed by immunoforesecence and in circulation antiepithelial autoantibodies are found. There is a correlation with MHC II class genes. Majority of Ashkenazi Jews having a diagnosis of pemphigus vulgaris have DRB1 allelle. Pemphigus vulgaris is caused by auto-antibodies against desmoglein(a glycoprotein that is present in desmosomes ,tight junctions between epithelial cells). Desmoglein has also been found in the mucous membranes epithelial cell junction that describes the involvement of eye in pemphigus vulgaris. The initial and common presentation is infammation as seen in all autoimmune phenomena. As pemphigus vulgaris is an autoimmune and infammatory disease, it responds well to immunosuppressive medication. Steroids are given intravenously/oral depending upon condition of patient and severity of the disease. There are various other immunosuppressive medicines e.g, azathioprine, cyclosporine, cyclophosphamide mycophenolate mofetil etc. Medical literature was sparse concerning ocular involvement in PV. In cooperation with the International Pemphigus Foundation a survey was undertaken to determine the prevalence and extent of ocular involvement in this rare disease. Methods After taking written informed consent hundred patients fulflling the inclusion criteria were included in the study and were questioned and examined according to the International Pemphigus Questionnaire that appeared in the Foundation’s website, discussion group and quarterly newsletter. A total of 158 responses were collected in 1999. Of these, 134 were from patients with PV and only those responses were considered. 1–7 Results This study included 100 pemphigus vulgaris patients who got admitted in the Indoor of Dermatology department, Mayo hospital during the year 2017 and 2018 upto month of May. The study was conducted based upon a questionnaire that included history of disease, its confrmation on biopsy and tzank smear and clinical examination of all mucosal surfaces to establish prevalence and pattern of eye involvement in the patients of pemphigus vulgaris. Eye involvement was found in 32 (32%) patients of which the most common symptom was found to be conjunctival redness which was found in 18 patients (18%). Eyelid skin involvement was also quite common in 17 patients (17%). Conjunctival discharge was found in 15% of patients. Blurring of vision was found in only 4(4%) of patients. Pain was quite common and noted in about 21 patients (21%).Eye involvement was found bilaterally in 27 patients (90% of patients with eye involvement) with 3 patients having unilateral eye involvement. Photophobia was present in 7 (7%) patients. Bulbar conjunctival erosions were found in 2 patients (2%).These all discussed problems were present during the course of pemphigus vulgaris and not present before or during the remission of the disease. These eye problems gradually got improved as systemic disease got improved during the treatment with systemic corticosteroids, immunosuppressants, local symptomatic treatment and eye care (Table 1). J Dermat Cosmetol. 2019;3(5):138‒140. 138 ©2019 Butt et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially. Prevalence of ocular involvement in pemphigus vulgaris patients in the dermatology department of Mayo Hospital Lahore Volume 3 Issue 5 - 2019 Ghazala Butt, M Arslan Ibrahim, Ahmad Raza, Uzair Wazir, Umara Siddique, Uzma Malik Department of Dermatology, Mayo Hospital, Pakistan Correspondence: Ghazala Butt, Assistant professor of Dermatology, Mayo Hospital, Pakistan, Email Received: February 21, 2019 | Published: October 31, 2019 Abstract Pemphigus vulgaris (PV) is a bullous disease. It has autoimmune etiology. It mainly affects skin along with mucous membranes. The frequency and pattern of involvement of eyes in this disease is not clearly defned till now. We decided to conduct a study of hundred patients with diagnosis of PV in a tertiary care hospital in Pakistan. The result showed a signifcant number of patients with eye involvement, 32 out of 100 cases in the indoor department of hospital i.e. (32%) showed eye involvement in a variable range of severity and presentation. Most common symptom was conjunctivitis followed by palpebral conjunctival erosions. Discharge was present in few patients that was either watery or mucoid due to the secondary infection. Keywords: pemphigus vulgaris, bullous disease, conjunctivitis, discharge Journal of Dermatology & Cosmetology Research Article Open Access