79 INTRODUCTION High Functioning Autism or Asperger's disorder (HFA/ AD) is a pervasive developmental disorder characterized by qualitative impairment in mutual social interaction, limitation in behavior, interest and activity, and repetitive patterns without a clinically significant delay in language and cognitive development. An important symptom may not occur in the first years of life, especially in the first 4 years (1). There are certain areas where the problem lies: speech, limited interests, and deterioration in social skills. As children with HFA/AD grow, the problems also change. During adolescence; additional mental disorders are common. About half of the patients have personal health and self-care problems. Problems related to integration due to difficulties in academic work and peer relations are noteworthy in the school. Social withdrawal becomes apparent between the ages of 13‒19 (2,3). The main purpose in the treatment of HFA/AD is to ensure the social harmony of the patient. In this context, when the variables affecting social adjustment in Asperger’s syndrome are examined; severity of the disorder, cognitive capacity of the patient, comorbidity, family and environmental factors are found as the main factors. When comorbidity was examined, it was found that 30% CASE REPORT High Functioning Autism or Asperger’s Disorder Follow-up Period: Detailed Retrospective Evaluation and Novel Status Determination of a Case and Prospective Guidance Mehmet Hamdi Orum 1 , Tezan Bildik 2 , Mahmut Zabit Kara 3 , Helin Yilmaz 2 , Hasan Akin Tahillioglu 2 , Aysun Kalenderoglu 1 1 Adiyaman University, School of Medicine, Department of Psychiatry, Adiyaman, Turkey 2 Ege University, School of Medicine, Department of Child and Adolescent Psychiatry, Izmir, Turkey 3 Adiyaman Training and Research Hospital, Child and Adolescent Psychiatry, Adiyaman, Turkey Psychiatry and Behavioral Sciences 2018;8(2):79-85 http://dx.doi.org/10.5455/jmood.20171205113628 ABSTRACT The main characteristic of high functioning autism or Asperger's disorder (HFA/AD) is severe and sustained impairment in social interaction as well as development of restricted, repetitive patterns of behaviour, interests and activities. Pharmacotherapy helps to alleviate some symptoms and signs of autism and autistic spectrum disorders (ASD). However, the main problem with these patients is the incompatibility of the drug with various reasons. In this article, a case with the diagnosis of HFA/AD followed in the same clinic for more than 10 years has been presented. The files are being examined retrospectively, discussing the difficulties encountered during the diagnosis in the presence of varying symptoms during the follow-up, and presenting results from 12-weeks prospective follow-up in the context of various tests.. Keywords: Asperger disorder, high functioning autism, adolescent, scale, psychopathology Corresponding author: Mehmet Hamdi Orum, Adiyaman University, School of Medicine, Department of Psychiatry, Adiyaman, Turkey E-mail: mhorum@hotmail.com Received: December 5, 2017 Accepted: February 13, 2018 Citation: Orum MH, Bildik T, Kara MZ, Yilmaz H, Tahillioglu HA, Kalenderoglu A. High functioning autism or asperger’s disorder follow-up period: detailed retrospective evaluation and novel status determination of a case and prospective guidance. Psychiatry and Behavioral Sciences 2018;8(2):79-85. https://doi.org/10.5455/jmood.20171205113628