1 Title page 1 Running title: Visceral Adiposity, Insula, and Food Craving 2 3 Visceral Adiposity and Insular networks: 4 Associations with Food Craving 5 6 7 Oren Contreras-Rodríguez 1,2* , Cano M 1,2,3 , Raquel Vilar-López 4,5,6 , Jacqueline 8 Schmidt Rio-Valle 7 , Juan Verdejo-Román 4 , Juan F Navas 4,8 , Cristina Martín-Pérez 5,6 , 9 Fernando Fernández-Aranda 1,9 , José Manuel Menchón 1,2 , Carles Soriano-Mas 1,2,10 *, 10 Antonio Verdejo-García 6,11 11 1. Psychiatry Department, Bellvitge University Hospital, Bellvitge Biomedical Research 12 Institute-IDIBELL, Barcelona Spain 13 2. Ciber en Salud Mental (CIBERSAM-17), Instituto Salud Carlos III, Barcelona, Spain 14 3. Department of Clinical Sciences, School of Medicine, University of Barcelona, Spain 15 4. Mind, Brain and Behavior Research Center, University of Granada, Spain 16 5. Departamento de Personalidad, Evaluación y Tratamiento Psicológico 17 6. Red de Trastornos Adictivos, University of Granada, Spain 18 7. Department of Nursing, School of Health Sciences. Universidad de Granada, Spain. 19 8. Department of Experimental Psychology, University of Granada, Spain 20 9. Ciber en Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto Salud 21 Carlos III, Barcelona, Spain 22 10. Department of Psychobiology and Methodology of Health Sciences, Autonomous 23 University of Barcelona, Spain. 24 11. School of Psychological Sciences and Monash Institute of Cognitive and Clinical 25 Neurosciences, Monash University, Melbourne, Australia 26 27 Number of words: Abstract 269; Text body 3080 28 The submission contains: The main Text file, 3 Figures, 2 Tables, 1 Supplementary 29 Information file 30 31 *Address correspondence to Carles Soriano-Mas and Oren Contreras-Rodríguez. 32 Psychiatry Department, Bellvitge University Hospital, Bellvitge Biomedical Research 33 Institute-IDIBELL, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona. 34 Tel: (+34) 93 2607500 (ext.2864) Fax: (+34 932607658) 35 Email: csoriano@idibell.cat, ocontreras@idibell.cat 36 37 Conflict of Interest Statement: The authors declare no conflict of interest. This study 38 has been funded by the Project Grant NEUROCOBE (PI-HUM-6635) from the 39 Andalusian Council of Innovation, Science and Industry to Dr. Soriano-Mas is funded 40 by a ‘Miguel Servet’ contract (CPII16/00048) and Dr. Oren Contreras-Rodriguez is 41 funded by a ‘Sara Borrell’ postdoctoral fellowship (CD14/00246) from the Carlos III 42 Health Institute (ISCIII). Juan Francisco Navas is funded by a FPU predoctoral 43 fellowship (FPU13/00669) from the Spanish Ministry of Education, Culture and Sport. 44 CIBERSAM and CIBEROBN are both initiatives of ISCIII. 45