Journal of Reproductive Medicine and Family Planning 2018 | Volume 1 | Article 1001 01 © 2018 - MedText. All Rights Reserved. Metabolic Syndrome Component Changes Over a Decade, During the Menopausal Transition in Tehranian Women: Tehran Lipid and Glucose Study (TLGS) Research Article Golshan Amirshekari 1 , Elaheh Ainy 2 *, Fahimeh Ramezani Tehrani 1 , Marzieh Rostami Dovom 1 and Fereidoun Azizi 1 1 Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2 Research affair, Safety Promotion, and Injury Prevention Research Center of Shahid Beheshti University of Medical Sciences, Tehran, Iran Introduction MetS is a group of risk factors that increase the risk of heart diseases, diabetes and, strokes, with a prevalence rate of 13.8% to more than 60.0% in various populations [1-4]. Menopausal transition is considered to be a risk factor for MetS, probably due to the decreasing estrogen levels and increasing insulin resistance, secondary to the menopause determinates [3,5,6]. Additionally, post- menopause, as a period of hyperandrogenism due to ovarian failure, is accompanied by increasing levels of LDL and decreased levels of HDL cholesterol, associated with MetS [7,8]. Independent of age, postmenopausal and premenopausal periods have higher triglyceride and lower high-density lipoprotein cholesterol (HDL-C) levels [9]. Some studies [10,11], afer age adjustment, showed no signifcant diferences among the mentioned components. Longitudinal studies showed the same results [12,13]. One study in Japan showed that menopause was associated with an increase in the total cholesterol levels or in the level of blood pressure [14]. Our previous study, ten years ago, showed that the frequency of MetS was signifcantly higher in post-M women as compared to pre-M women; low HDL-c and high diastolic blood pressure was the most frequent feature in comparison to the other factors [15]. We aimed to use the data of TLGS to assess the MetS components changes over a decade, during the menopausal transition in Tehranian women. Methods  In a cross-sectional study, 1999 subjects were selected from 15005 participants of the Tehran Lipid and Glucose Cohort Study (TLGS) [16], who have further assessed for MetS components changes over a decade (2007–2017). We excluded 596 smokers and those who were current users of any hormone replacement therapy or oral contraceptives. 1403 women aged between 15–65 years, among 1999 participants of the TLGS, were classified into three groups: 1. Pre-M (pre-menopausal) women, aged between 45–49 years, 2. M (menopausal) women, with a permanent cessation of menses of less than 12 months and more than 3 years, and 3. Post-M (postmenopausal) Citation: Amirshekari G, Ainy E, Tehrani FR, Dovom MR, Azizi F. Metabolic Syndrome Component Changes Over a Decade, During the Menopausal Transition in Tehranian Women: Tehran Lipid and Glucose Study (TLGS). J Reprod Med Fam Plann. 2018; 1(1): 1001. Copyright: © 2018 by the Medtext Publications LLC Publisher Name: MedText Publications Manuscript compiled: September 06 th , 2018 *Corresponding author: Elaheh Ainy, Research affair, Safety Promotion, and Injury Prevention Research Center of Shahid Beheshti University of Medical Sciences, Tehran, Iran, E-mail: ainy.elaheh@gmail.com Abstract Background: Metabolic syndrome (MetS) is a group of risk factors that increase the risk of heart diseases, diabetes, and strokes. Objective: Tis study was conducted to assess the MetS component changes over a decade, during the menopausal transition in Tehranian women. Methods: In a cross-sectional study, 1,999 subjects were selected from 15,005 participants of the Tehran Lipid and Glucose Cohort Study (TLGS), who have further assessed for MetS components changes over a decade (2007–2017). We excluded 596 smokers and those who were current users of any hormone replacement therapy or oral contraceptives. 1403 women aged between 15–65 years, among all the participants of the TLGS, were classified into three groups: 1. Pre-M (pre-menopausal), women, aged between 45–49 years, 2. M (menopausal) women, with a permanent cessation of menses of less than 12 months and more than 3 years, and 3. Post-M (post-menopausal) women, who have had a history of a minimum of 3-years of cessation of menses. All the components of MetS were evaluated, following the age adjustment factor, according to the ATPIII criteria. Results: Te mean ages of pre-M, menopausal, and post-M groups were 46.8 ± 1.4, 52.8 ± 3.1, and 58.7 ± 4.9 years, respectively. Te prevalence of the metabolic syndrome was 33.9%. All the groups demonstrated an increase in the waist, and systolic blood pressure (p<0.001). Odd’s ratio, confdence interval, and the signifcance of some of the metabolic syndrome components were: Fasting plasma glucose (OR: 1.031, CI: 1.009-1.054, P<0.005), 2-hour blood glucose (OR: 1.011, CI: 1.004-1.018, P<0.003), triglyceride (OR: 1.023, CI: 1.019-1.028, P<0.002), HDL-c levels (OR: 0.89, CI: 0.865-0.918, P<0.005), and waist circumference (OR: 1.044, CI: 1.006-1.083, P<0.022). Conclusion: Over a decade, during the menopausal transition, the waist circumference and systolic blood pressure were associated with an increase in the metabolic syndrome. Keywords: Metabolic syndrome; Menopause; Aging; TLGS