Open Access Review Article Journal of Dental Health and Oral Research Saberi EA | Volume 3; Issue 2 (2022) | JDHOR-3(2)-046 | Review Article Citation: Saberi EA, et al. Post-Endodontic Pain after Root Canal Treatment of Symptomatic Teeth with Mtwo and Safe Sider Multiple File Systems: A Randomized Clinical Trial. J Dental Health Oral Res. 2022;3(2):1-11. DOI: https://doi.org/10.46889/JDHOR.2022.3201 Post-Endodontic Pain after Root Canal Treatment of Symptomatic Teeth with Mtwo and Safe Sider Multiple File Systems: A Randomized Clinical Trial Eshagh Ali Saberi 1* , Narges Farhad-Mollashahi 1 , Arezoo Hooshmandi 2 , Arezoo Pirhaji 3 1 Department of Endodontics, Faculty of Dentistry, Oral and Dental Diseases Research Center, Zahedan University of Medical Sciences, Zahedan, Iran 2 Department of Endodontics, Kerman University of Medical Sciences, Kerman, Iran 3 Department of Endodontics, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran * Corresponding Author: Eshagh Ali Saberi, Department of Endodontics, Faculty of Dentistry, Oral and Dental Diseases Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; Email: saberiendo@yahoo.com Received Date: 22-04-2022; Accepted Date: 12-05-2022; Published Date: 19-05-2022 Copyright © 2022 by Saberi EA, et al. All rights reserved. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. Abstract Background: Considering the increasing popularity of rotary files among dental clinicians and the emergence of several types of rotary systems, clinical trials are necessary to compare these systems from various aspects. Objectives: This study compared post-endodontic pain following the use of Mtwo and Safe Sider multiple file system. Methods: A total of 150 maxillary and mandibular molars with symptomatic irreversible pulpitis were selected. Their root canals were randomly instrumented with hand files, Mtwo and Safe Sider instruments. The severity of postoperative pain was assessed using a Visual Analog Scale (VAS) at 6, 12, 24, 48 and 72 hours. The data were analyzed using repeated measures ANOVA. P<0.05 was considered statistically significant. Results: The mean postoperative pain score significantly decreased in all three groups over time. The mean pain score at 12 and 24 hours post-treatment was significantly higher in the