Authors: Carolee Winstein, PT, PhD, FAPTA Patricia Pate, MPT, NCS Tingting Ge, MS Carolyn Ervin, PhD James Baurley, MS Katherine J. Sullivan, PT, PhD Samantha J. Underwood, MS Eileen G. Fowler, PT, PhD Sara Mulroy, PT, PhD David A. Brown, PT, PhD Kornelia Kulig, PT, PhD James Gordon, PT, EdD, FAPTA Stanley P. Azen, PhD Physical Therapy Clinical Research Network (PTClinResNet)* Affiliations: From the Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, Los Angeles, California (CW, PP, KJS, KK, JG); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California (TG, CE, JB, SPA); Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, Los Angeles, California (SJU); Department of Surgery, Oregon Heath & Science University, Portland, Oregon (SJU); University of California, Los Angeles, Los Angeles, California (EGF); Rancho Los Amigos National Rehabilitation Center, Downey, California (SM); and Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (DAB). 0894-9115/08/8711-0937/0 American Journal of Physical Medicine & Rehabilitation Copyright © 2007 by Lippincott Williams & Wilkins The Physical Therapy Clinical Research Network (PTClinResNet) Methods, Efficacy, and Benefits of a Rehabilitation Research Network ABSTRACT Winstein C, Pate P, Ge T, Ervin C, Baurley J, Sullivan KJ, Underwood SJ, Fowler EG, Mulroy S, Brown DA, Kulig K, Gordon J, Azen SP; Physical Therapy Clinical Research Network (PTClinResNet): The Physical Therapy Clinical Research Network (PTClinResNet): methods, efficacy, and benefits of a rehabilitation research network. Am J Phys Med Rehabil 2008;87:937–950. This article describes the vision, methods, and implementation strategies used in building the infrastructure for PTClinResNet, a clinical research network de- signed to assess outcomes for health-related mobility associated with evidence- based physical therapy interventions across and within four different disability groups. Specific aims were to (1) create the infrastructure necessary to develop and sustain clinical trials research in rehabilitation, (2) generate evidence to evaluate the efficacy of resistance exercise– based physical interventions de- signed to improve muscle performance and movement skills, and (3) provide education and training opportunities for present and future clinician–researchers and for the rehabilitation community at-large in its support of evidence-based practice. We present the network’s infrastructure, development, and several examples that highlight the benefits of a clinical research network. We suggest that the network structure is ideal for building research capacity and fostering multisite, multiinvestigator clinical research projects designed to generate evi- dence for the efficacy of rehabilitation interventions. Key Words: Multisite Clinical Trials, Medical Rehabilitation, Outcomes Research, Disablement Model, Biomedical Informatics, Physical Therapy November 2008 CT Clinical Research Network 937 REPORT & REVIEW Outcomes