Developing a phenomenological equation to predict yield strength from composition and microstructure in  processed Ti-6Al-4V I. Ghamarian 1 , B. Hayes 2 , P. Samimi 1 , B. A. Welk 3 , H. L. Fraser 3 , P. C. Collins 1,* 1 – Formerly with the Department of Materials Science and Engineering, University of North Texas, Denton, TX 76203, USA, now with the Department of Materials Science and Engineering, Iowa State University, Ames, IA, 50011 2 – Department of Materials Science and Engineering, University of North Texas, Denton, TX 76203, USA 3 – Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA Abstract A constituent-based phenomenological equation to predict yield strength values from quantified measurements of the microstructure and composition of  processed Ti-6Al-4V alloy was developed via the integration of artificial neural networks and genetic algorithms. It is shown that the solid solution strengthening contributes the most to the yield strength (~80% of the value), while the intrinsic yield strength of the two phases and microstructure have lower effects (~10% for both terms). Similarities and differences between the proposed equation and the previously established phenomenological equation for the yield strength prediction of the + processed Ti-6Al-4V alloys are discussed. While the two equations are very similar in terms of the intrinsic yield strength of the two constituent phases, the solid solution strengthening terms and the ‘Hall-Petch’-like effect from the alpha lath, there is a pronounced difference in the role of the basketweave factor in strengthening. Finally, Monte Carlo simulations were applied to the © 2016. This manuscript version is made available under the Elsevier user license http://www.elsevier.com/open-access/userlicense/1.0/