~ 1224 ~ Journal of Entomology and Zoology Studies 2018; 6(3): 1224-1225 E-ISSN: 2320-7078 P-ISSN: 2349-6800 JEZS 2018; 6(3): 1224-1225 © 2018 JEZS Received: 16-03-2018 Accepted: 17-04-2018 Vipin Singh Department of Veterinary Gynaecology and Obstetrics, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, Uttar Pradesh, India Vikas Sachan Department of Veterinary Gynaecology and Obstetrics, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, Uttar Pradesh, India Akhil Patel Department of Veterinary Gynaecology and Obstetrics, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, Uttar Pradesh, India Atul Saxena Department of Veterinary Gynaecology and Obstetrics, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, Uttar Pradesh, India Correspondence Vipin Singh Department of Veterinary Gynaecology and Obstetrics, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, Uttar Pradesh, India Therapeutic and surgical management of open cervix pyometra in a bitch Vipin Singh, Vikas Sachan, Akhil Patel and Atul Saxena Abstract An intact seven year old unspayed female Labrador dog with history of vomition, vaginal discharge, distended abdomen, anorexia, polyurea, and pyrexia was presented to Teaching Veterinary Clinical Complex, Veterinary Reproduction Division, Mathura. Based on the history, clinical signs & symptoms, clinical pathology and ultrasonography reports the condition was diagnosed as open cervix pyometra and the pyometra was successfully managed by Ovario-hysterectomy. Keywords: Labrador, pyometra, Ovario-hysterectomy, ultrasonography Introduction The incidence of pyometra in dogs is approximately 24% before 10 years of age, Hagman et al. [1] and most commonly occurs in middle aged female dogs that have not been spayed and a hormonal mediated diestural disorder that results in abnormal uterine endomentrium by Amstutz et al. [2] . Pyometra is the accumulation of pus within the uterus due to progesterone dominance, is classified as open and closed cervix pyometra. In open cervix pyometra, bitches are less systemically affected than in closed cervix pyometra. Common clinical signs include mucopurulent discharges, inappetence, depression, polydipsia, polyuria, lethargy, vomiting, diarrhoea and abdominal distension. The increased progesterone levels stimulate uterine glandular secretions and create the ideal conditions for infection within the uterus, which suppresses uterine contractions, Cox. [3] Once the uterus is infected, it can become filled with purulent material and progress to become a life threatening condition. Anoop et al. [4] , Pyometra is mainly caused by E. coli, Klebisiella, Pasterurella and Staphylococcus; most of organism is gram negative bacteria by Okano et al. [5] and in approximately 90% of cases, Escherichia coli are the main causative agent by Susi et al. [6] . Endotoxins produced by these bacteria initiated the cytokine cascade and release of many inflammatory mediators responsible for renal failure due to deleterious effect of toxin on kidney. The aims of the present study were to describe complications of the disease with therapeutic and surgical management of bitch affected with open cervix pyometra. Case History and Clinical signs A seven year old unspayed female Labrador dog with history of vomition, vaginal discharge distended abdomen, anorexia, polyurea, and pyrexia was presented to TVCC, DUVASU, Mathura. On clinical examination bitch suffered with vaginal discharge (figure: 1), Rectal temperature was 104.6°F, heart rate 160 b/m, respectively. Ultrasonography was done with the Real time B mode ultrasound apparatus with 6.5 MHz convex transducer using the trans- abdominal approach. During the examination of the uterus showed an extremely enlarged anechoic fluid-filled lumen (sacculations in both the horns) and a thickened wall of the uterus (figure: 2) Haematology revealed PCV-17.20. TLC (Total Leucocyte Count) -52, 00/cu mm, Haemoglobin (Hb)-5.80 GM % and RBC (Red Blood Cell Count) - 2.43 millions/cm m. The visible conjuctival mucous membrane was pale, dry and congested indicative of toxaemia and dehydration. Serum biochemistry parameters like blood urea nitrogen, creatinine, sodium, calcium, total protein and serum albumin were 16.8 mg/dl, 0.97 mg/dl, 126.8 m mol/l, 8.14 mg/dl, 5.88gm % and 2.62gm %. These serum biochemistry parameters indicate renal involvement and uremic gastritis. On the basis of clinical findings, it was confirmed as open cervix pyometra hence, surgery was planned and fasting was advised.