Accepted Article NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder Jonathan Lévy 1,2* , Sarah Grotto 1* , Cyril Mignot 3,4 , Céline Dupont 1 , Andrée Delahaye 2,5 , Brigitte Benzacken 2,5 , Boris Keren 3 , Damien Haye 3 , Jean Xavier 6 , Mathilde Heulin 7 , Emilie Charles 7 , Alain Verloes 1,2 , Anna Maruani 8,9 , Eva Pipiras 2,5* , Anne-Claude Tabet 1,9* *contribute equally to this paper 1 Genetics Department, AP-HP, Robert-Debré University Hospital, Paris, France 2 INSERM UMR1141, Paris Diderot University, AP-HP, Robert-Debré Hospital, Paris, France 3 Genetics Department, AP-HP, Pitié-Salpêtrière Hospital, Paris, France 4 Centre de Référence Déficience Intellectuelle de Causes Rares, GRC UPMC « Déficience Intellectuelle et Autisme », Pitié-Salpêtrière Hospital, Paris, France 5 Department of Cytogenetics, Jean-Verdier Hospital, Paris 13 University, Embryology and Histology, AP-HP, Bondy, France 6 Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, AP-HP, Paris, France 7 Unité de Diagnostic et d'Evaluation Pluriprofessionnelle de l'autisme et des troubles apparentés, Etablissement publique de santé de Ville- Evrard, Neuilly Sur Marne, France 8 Child and Adolescent Psychiatry Department, Robert-Debré Hospital, AP-HP, Paris, France. 9 Neuroscience Department, Génétique Humaine et Fonction Cognitive Unit, Pasteur Institute, Paris, France Correspondence to: Dr. Jonathan Levy Robert-Debré University Hospital, 48 Bd Sérurier, 75019 Paris, France Email address: jonathan.levy@aphp.fr ACKNOWLEDGEMENTS The authors thank the patients and their family for participating in this study, and the Robert-Debré University Hospital for its full support. Conflict of interest: The authors declare no conflict of interest. Ethics approval: Written informed consent was received from the patients. The authors adhere to the Declaration of Helsinki Principles. Experiments were approved by the Comité d’Ethique of Robert- Debré University Hospital. This article is protected by copyright. All rights reserved. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/cge.13383