!" #$%$& ’($ )*! +),-.,*! !/ ,*0#!1,- ,#*)*2 !/ ,3 4,5, 3+6,7, +4, ,*,*42 8 , 5 4),*,), ,3 ,,, 4),*,), ab Swami Shri Swaroopanand Saraswati Mahavidyalaya, Hudco, Bhilai, Chhattisgarh, India c Govt. D.T. Utai College, Durg, Chhattisgarh, India d Govt. V.Y.T.P.G. Autonomous College, Durg, Chhattisgarh, India ,1*,#* " 9( :$8" ;< ; %$" : 9( " == *( 9 :< ; $:%$’ "" % :< :" %" 9(( (; < $ 8 $; !"< ( $ (: =$ ( %$" :$8" %$%< *( ’< : $ ;"’ ( :$8" ; $= 9$ :" %" > & 5+26!3 Antimicrobial Activity, Natural products of either plants or animals were used in human civilization as the main source of medicine from the ancient period. Plants and their extracts were used as traditional herbal medicine for a long time by ancient peoples to cure all kinds of diseases (Sowjanya et. al., 2013). Secondary metabolites of various medicinal plants are rich source of medicine and developing rapidly in practice challenging the modern medicine (Lutterodt et. al., 1999). In developing countries the traditional herbal medicines is used for primary treatment and considered as an important health care system. Various parts of plants such as leaves, roots, seeds, fruits, flowers etc were used traditionally and were found to have potential antimicrobial properties (Sowjanya et. al., 2013). Plants with antimicrobial activity can serve as potential medicine with lesser side effects. There were many active compounds still present in many medicinal plants which have yet to be discovered. Only the need is to screen them for their potential antimicrobial property. This study aims to evaluate the antimicrobial activities of two medicinal plants – and against and . belongs to family Begnoniaceae, is a native plant of America. It is a large shrub, much branched with 10625cm long compound leaves. Flowers are bright yellow in color, tubular in shape and born in clusters. Its flower gives an attractive look to the plants and thus in homes, gardens, road sides etc. it is planted as show plant. Fruits are large, elongated with flat seeds. The plant was used traditionally in Mexico and Central America for diabetic and urinary disorders. Leaves of plant contain many biologically active chemicals such as various types of alkaloids, flavinoids, steroids, tannins, phytosterols, hydrocarbons, resins, volatile oil, glycosides etc. (Raju et. al., 2011). Various primary and secondary metabolites such as sugar, alkaloids, triterpenoids and phenolics were identified in the whole plant of (Dohnal, 1976). Literature survey reveals that possess various bio active compounds exhibiting antioxidant, antibacterial and antimicrobial activities (Karou et. al., 2006). It shows antimicrobial property against many pathogenic bacteria such as species specie (Senthilkumar et. al., 2010) etc. Its leave and stem extract contain significant antibacterial property against some species of (Salem et. al., 2013) etc. It also contains a potent antifungal property against (Javid et. al., 2015). Tecomine isolated from possess potential hypoglycemic effect in animals (Amad et. al., 2012, Raju et. al., 2011). , commonly known as nirgundi belongs to family Verbenaceae, is a woody, large aromatic shrub bearing tri or penta foliate leaves. Its flower is bluish purple in color. It is native to tropical Eastern and Southern Africa and Asia. Number of active phytochemical compounds was found in plant extract of nirgundi. It has been found that serve as an important medicinal plant and used traditionally to cure various diseases in many countries in Asia (Chowdhary et. al., 2010). It contains many types of phytochemicals compounds such as volatile oils, flainoids, terpens, steroids (Banerji et. al.,1988, Dayal R. and Singh V., 2000, Maurya et. al., 2007)etc.