Accepted Manuscript Optimization of Linalool-loaded Solid Lipid Nanoparticles using Experimental Factorial Design and Long-term Stability Studies with a New Centrifugal Sed- imentation Method Irina Pereira, Zielińska, Nuno R. Ferreira, Amélia M. Silva, Eliana B. Souto PII: S0378-5173(18)30553-2 DOI: https://doi.org/10.1016/j.ijpharm.2018.07.068 Reference: IJP 17684 To appear in: International Journal of Pharmaceutics Received Date: 8 February 2018 Revised Date: 26 July 2018 Accepted Date: 30 July 2018 Please cite this article as: I. Pereira, Zielińska, N.R. Ferreira, A.M. Silva, E.B. Souto, Optimization of Linalool- loaded Solid Lipid Nanoparticles using Experimental Factorial Design and Long-term Stability Studies with a New Centrifugal Sedimentation Method, International Journal of Pharmaceutics (2018), doi: https://doi.org/10.1016/ j.ijpharm.2018.07.068 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.