Open Access Library Journal 2021, Volume 8, e7464 ISSN Online: 2333-9721 ISSN Print: 2333-9705 DOI: 10.4236/oalib.1107464 Jul. 1, 2021 1 Open Access Library Journal Hemophagocytic Lymphohistiocytosis and Atypical Uremic Syndrome Associated with Weil Syndrome Nuria Citlalli Luna-Silva 1 , Alexis Gomez-Pardo 1 , Heliodora Jimenez-Hernandez 2 , Victoria Isabel Castañeda-Avila 3 , Cesar Daniel Alonso-Bello 4* 1 Pediatrics Department, Hospital de la Niñez Oaxaqueña, Oaxaca, Mexico 2 Hematology Laboratory, Hospital de la Niñez Oaxaqueña, Oaxaca, Mexico 3 Gynecology and Pediatrics 3A Hospital, Instituto Mexicano del Seguro Social, Mexico City, Mexico 4 Angeles Roma Hospital, Angeles Medical Group, Mexico City, Mexico Abstract In 1886, the German internist Adolph Weil described for the first time a dis- ease caused by the spirochete family of the genus Leptospira spp., causing the infectious disease called leptospirosis or Weil Syndrome in a systemic stage. The disease is transmitted by direct contact with infected animals, which eli- minates the bacteria through urine or by contact with the soil and water where they live. Hemophagocytic Lymphohistiocytosis (HLH) or hemopha- gocytic syndrome, is a syndrome caused by immunological activation involv- ing different organs. It has also been documented, as a cause of Atypical He- molytic Uremic Syndrome (aHUS) rarely. In this report, we describe an ex- tremely rare clinical presentation of leptospirosis (Weil Syndrome), asso- ciated with HLH and aHUS, an association with great clinical relevance. The syndrome that until today has not been described is the first case report, made formally in the medical literature. Subject Areas Infectious Diseases, Internal Medicine Keywords Leptospirosis, Hemophagocytic, Lymphohistiocytosis, Hemolytic Uremic Syndrome 1. Introduction In 1886, the German internist Adolph Weil described for the first time a disease How to cite this paper: Luna-Silva, N.C., Gomez-Pardo, A., Jimenez-Hernandez, H., Castañeda-Avila, V.I. and Alonso-Bello, C.D. (2021) Hemophagocytic Lym-pho- histiocytosis and Atypical Uremic Syndrome Associated with Weil Syndrome. Open Access Library Journal, 8: e7464. https://doi.org/10.4236/oalib.1107464 Received: April 28, 2021 Accepted: June 28, 2021 Published: July 1, 2021 Copyright © 2021 by author(s) and Open Access Library Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access