International Journal of Sciences: Basic and Applied Research (IJSBAR) ISSN 2307-4531 (Print & Online) http://gssrr.org/index.php?journal=JournalOfBasicAndApplied --------------------------------------------------------------------------------------------------------------------------- 70 Framingham Risk Score (FRS) as Risk Factor of Stroke Saugi Abduh a , Indah Wardani b , Siti Thomas Zulaikhah c* a Departement of Intenal Medicine, Faculty of Medicine, Universitas Islam Sultan Agung, Jln. Raya Kaligawe KM. 4 Semarang, 50112 b Student of Faculty of Medicine, Universitas Islam Sultan Agung, Jln. Raya Kaligawe KM. 4 Semarang, 50112 c Departement of Public Health, Faculty of Medicine, Universitas Islam Sultan Agung, Jln. Raya Kaligawe KM. 4 Semarang, 50112 a Email: drsaugiabduh@yahoo.com b Email: wardaniindah@yahoo.com c Email: sitithomas@unissula.ac.id Abstract Stroke is the leading cause of death and disability in many parts of the world, including Indonesia. Stroke incidence has been increasing. A number of stroke risk factors have been identified, Framingham Risk Score (FRS) can be used as a predictor of stroke. This study aimed to determine the relationship between FRS and stroke. Methods: This was a cross-sectional study among 70 consecutive in-patients at Sultan Agung Islamic Hospital, Semarang, Indonesia. The data were obtained from medical records were analyzed using Chi Square for bivariate test and multiple logistic regression for multivariate test. The result of bivariate analysis showed a significant relationship between total FRS and stroke with p = 0.018 (<0.05), while components of FRS correlated to stroke were age (p = 0.034), diabetes mellitus (DM) (p = 0.046), hypertension (p = 0.037), hypertension treatment (p = 0.015) and smoking (p = 0.031). The results of multivariate analysis for each component showed that the most dominant FRS associated with stroke was DM (PR = 8.522; 95% CI = 1.736 - 41.846). There was a relationship between total FRS and stroke. Risk factors of FRS components associated with stroke were age, hypertension, DM, hypertension and smoking. DM was the most dominant risk factor associated with stroke, patients with DM has 8.522 times higher risk of developing stroke compared to those without. Keywords: Stroke; Framingham Risk Score; Diabetes mellitus. ------------------------------------------------------------------------ * Corresponding author.