_____________________________________________________________________________________________________ *Corresponding author; Journal of Advances in Medicine and Medical Research 34(14): 16-30, 2022; Article no.JAMMR.86526 ISSN: 2456-8899 (Past name: British Journal of Medicine and Medical Research, Past ISSN: 2231-0614, NLM ID: 101570965) Clinical Significance of Haematologic Indices as Indicators for Systemic Lupus Erythematosus Activity Samar Darwish Mostafa Alhelby a* , Hossam AbdElmohsen Hodeib b , Amr Mohamed Gawaly a and Ebaa Hussein El-Sheikh a a Department of Internal Medicine, Faculty of Medicine, Tanta University, Egypt. b Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JAMMR/2022/v34i1431385 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/86526 Received 18 February 2022 Accepted 26 April 2022 Published 05 May 2022 ABSTRACT Background: Lupus erythematosus is a diverse autoimmune disorder that is capable of afflicting a variety of organs and has a clinical history that is inconsistent. Despite substantial improvements in systemic lupus erythematosus (SLE) patient survival, the pathophysiology of the disease remains unexplained, despite the fact that genes play a key role in its propensity. Objective: To evaluate the several hematological indicators (neutrophil- to- lymphocyte ratio (NLR), platelet -to- lymphocyte ratio (PLR), platelet distribution width (PDW), red cell distribution width (RDW), mean platelet volume (MPV) in SLE patients and their correlation with disease manifestations. Patients and Methods: In our study, a cross-sectional comparative study that enrolled 100 SLE patients (30 male and 70 female patients) aged from 18-55y who are recruited from the Internal Medicine Department, Rheumatology Unit (inpatient wards and outpatient clinics) the patients were categorized into three groups according to the (SLE disease activity index 2000. (SLEDAI-2K): Group (I): Inactive (SLEDAI-2K, <6) Include thirty-one patients. Group (II): Moderately active (SLEDAI-2K, 6-10) Include twenty-nine patients. Group (III): Highly active (SLEDAI-2k, ≥11) Include forty patients. Original Research Article