Accepted Manuscript Discovery, synthesis, selectivity modulation and DMPK characterization of 5- azaspiro[2.4]heptanes as potent orexin receptor antagonists Luigi Piero Stasi, Roberto Artusi, Clara Bovino, Benedetta Buzzi, Luca Canciani, Gianfranco Caselli, Fabrizio Colace, Paolo Garofalo, Silvia Giambuzzi, Patrice Larger, Ornella Letari, Stefano Mandelli, Lorenzo Perugini, Sabrina Pucci, Matteo Salvi, PierLuigi Toro PII: S0960-894X(13)00280-1 DOI: http://dx.doi.org/10.1016/j.bmcl.2013.02.093 Reference: BMCL 20211 To appear in: Bioorganic & Medicinal Chemistry Letters Received Date: 29 January 2013 Revised Date: 17 February 2013 Accepted Date: 20 February 2013 Please cite this article as: Stasi, L.P., Artusi, R., Bovino, C., Buzzi, B., Canciani, L., Caselli, G., Colace, F., Garofalo, P., Giambuzzi, S., Larger, P., Letari, O., Mandelli, S., Perugini, L., Pucci, S., Salvi, M., Toro, P., Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists, Bioorganic & Medicinal Chemistry Letters (2013), doi: http://dx.doi.org/10.1016/j.bmcl.2013.02.093 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.