Author’s Accepted Manuscript Oxidative stress mediated by lipid metabolism contributes to high glucose-induced senescence in retinal pigment epithelium Qingqiu Chen, Li Tang, Guang Xin, Shiyi Li, Limei Ma, Yao Xu, Manjiao Zhuang, Qiuyang Xiong, Zeliang Wei, Zhihua Xing, Hai Niu, Wen Huang PII: S0891-5849(18)31335-2 DOI: https://doi.org/10.1016/j.freeradbiomed.2018.10.419 Reference: FRB13983 To appear in: Free Radical Biology and Medicine Received date: 4 August 2018 Revised date: 9 October 2018 Accepted date: 10 October 2018 Cite this article as: Qingqiu Chen, Li Tang, Guang Xin, Shiyi Li, Limei Ma, Yao Xu, Manjiao Zhuang, Qiuyang Xiong, Zeliang Wei, Zhihua Xing, Hai Niu and Wen Huang, Oxidative stress mediated by lipid metabolism contributes to high glucose-induced senescence in retinal pigment epithelium, Free Radical Biology and Medicine, https://doi.org/10.1016/j.freeradbiomed.2018.10.419 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. www.elsevier.com