JPET # 257600 1 Quantitative contribution of six major transporters to the hepatic uptake of drugs: ‘SLC-phenotyping’ using primary human hepatocytes Yi-an Bi, Chester Costales, Sumathy Mathialagan, Mark West, Soraya Eatemadpour, Sarah Lazzaro, Laurie Tylaska, Renato Scialis, Hui Zhang, John Umland, Emi Kimoto, David A. Tess, Bo Feng, Larry M. Tremaine, Manthena V. S. Varma, A. David Rodrigues Medicine Design, Worldwide Research and Development, Pfizer Inc., Groton, CT 06340. This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on April 11, 2019 as DOI: 10.1124/jpet.119.257600 at ASPET Journals on January 25, 2022 jpet.aspetjournals.org Downloaded from