1 MANUSCRIPT Genome-wide association study on 13,167 individuals identifies regulators of hematopoietic stem and progenitor cell levels in human blood Aitzkoa Lopez de Lapuente Portilla 1,2 , Ludvig Ekdahl 1,2,* , Caterina Cafaro 1,2,* , Zain Ali 1,2,* , Natsumi Miharada 1,2 , Gudmar Thorleifsson 3 , Kristijonas Žemaitis 1,2 , Antton Lamarca Arrizabalaga 1,2 , Malte Thodberg 1,2 , Maroulio Pertesi 1,2 , Parashar Dhapola 1,2 , Erik Bao 4,5,6 , Abhishek Niroula 1,2,6 , Divya Bali 1,2 , Gudmundur Norddahl 3 , Nerea Ugidos Damboriena 1,2 , Vijay G. Sankaran 4,5,6 , Göran Karlsson 1,2 , Unnur Thorsteinsdottir 3 , Jonas Larsson 1,2 , Kari Stefansson 3 , Björn Nilsson 1,2,6 1 Lund Stem Cell Center, Lund University, 221 84 Lund, Sweden. 2 Department of Laboratory Medicine, Lund University, 221 84 Lund, Sweden. 3 deCODE genetics/Amgen Inc., 101 Reykjavik, Iceland. 4 Division of Hematology and Oncology, Boston Children’s Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. 5 Harvard Stem Cell Institute, Cambridge, MA 02215, USA. 6 Broad Institute, Cambridge, MA 02142, USA. * Equal contribution (shared second authors). Correspondence: Björn Nilsson, M.D. Ph.D., Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, 221 84 Lund, Sweden; e-mail: bjorn.nilsson@med.lu.se, tel +46-46-2220738, fax +46-46-130064. . CC-BY-NC-ND 4.0 International license made available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is The copyright holder for this preprint this version posted April 3, 2021. ; https://doi.org/10.1101/2021.03.31.437808 doi: bioRxiv preprint