30 Page 30-39 © MAT Journals 2019. All Rights Reserved Recent Trends in Pharmaceutical Sciences and Research Volume 1 Issue 2 A Review on Emulgel, as a Novel Trend in Topical Drug Delivery System Sanjay K Jain 1* , Pawan Bajapi 1 , Shailendra K Modi 1 , Prashant Gupta 2 , 1 Assistant Professor, 2 Associate Professor Daksh Institute of Pharmaceutical Science, Chhatarpur, Madhya Pradesh, India Email: *sanjayjain6884@gmail.com DOI: http://doi.org/10.5281/zenodo.3139463 Abstract These days, there is an upsurge in topical formulations such that it can be prepared by varying physicochemical properties and providing better localized action. The topical formulation is significant to patient for chronic skin diseases, like fungal infections, acne, and psoriasis. In NDDS (Novel Drug Delivery System), Emulgel is one of the recent technology used topically having characteristics of dual control release i.e. emulsion as well as gel. When gels and emulsions are used in combined form the dosage form are known as emulgel. Limitation of gels in the delivery of hydrophobic drugs through the skin. Overcome this limitation an emulsion based approach is being used so that even a hydrophobic therapeutic moiety can exhibit the unique properties of gels. Emulgel is prepared by different polymers which act as an emulsifying agent and thickening agent because the gelling capacity of these polymers give rise to stable emulsions and creams by decreasing interfacial and surface tension while at the same time increasing the viscosity of the aqueous phase. Emulgel are having major advantages on novel vesicular systems as well as on conventional systems considering various aspects. The emulgel provide several favourable properties for its dermatological use such as greaseless, thixotropic, easily spreadable, emollient, easily removable, non-staining, water soluble, longer shelf life, transparent, bio-friendly and pleasing appearance. Keywords: Emulgel, Polymer, Topical drug delivery INTRODUCTION For topical administration skin is one of the most readily accessible parts of human body and molecules penetrate in the skin mainly by three routes: through intact stratum corneum, through sweat ducts, and through the sebaceous follicle [1]. Topical drug delivery is used for localized action on the body through ophthalmic, rectal, vaginal and skin as topical routes. The topical drug delivery system such as emulgel (gellified emulsion) generally used where the other systems of drug administration fails to directly treat cutaneous disorders such as fungal infections, acne, psoriasis etc. Absorption of drug through the skin is enhanced if the drug substance present in solution, if lipid/water partition coefficient of drug substances has favourable and if it is a nonelectrolyte [2]. For the most of the time, pharmaceutical formulation applied to the skin are intended to serve some local action and as such preparations are formulated to provide prolonged local contact with minimal systemic drug absorption. Drug such as antiseptics, antifungal agent, skin emollients are applied to the skin for their local action. Avoidance of first pass metabolism is the main advantage of topical drug delivery system, it also Avoid the risks and inconveniences of intravenous therapy and of the varied conditions of absorption like pH changes, presence of different enzymes, gastric emptying time are other advantages of topical preparations. The transparent gels use has been expanded