1 3 J IRAN CHEM SOC DOI 10.1007/s13738-015-0634-8 ORIGINAL PAPER Ultrasound-assisted multi-component synthesis of indazolophthalazine derivatives Milad Pedarpour Vajargahy 1 · Minoo Dabiri 1 · David MaGee 2 · Ayoob Bazgir 1 Received: 6 October 2014 / Accepted: 14 March 2015 © Iranian Chemical Society 2015 Keywords Indazolophthalazine · Ultrasonic-assisted multi-component reaction · 2-Hydroxynaphthalene-1-4- dione · Phthalhydrazide · 2-5-Dihydroxycyclohexa-2-5- diene-1-4-dione Introduction A major challenge of modern synthesis is to develop effi- cient cascades that provide maximum structural diversity Abstract An efficient multi-component synthesis of inda- zolophthalazine derivatives through the reaction of phthal- hydrazide, 2-hydroxynaphthalene-1,4-dione or 2,5-dihy- droxycyclohexa-2,5-diene-1,4-dione and active carbonyl compounds under ultrasonic irradiation is reported. This chemistry provides an efficient and promising synthetic strategy to diversity-oriented construction of the indazoloph- thalazine skeleton with potential biological activities. Graphical Abstract * Minoo Dabiri * Ayoob Bazgir a_bazgir@sbu.ac.ir 1 Department of Chemistry, Shahid Beheshti University, General Campus, 1983963113 Tehran, Iran 2 Department of Chemistry, University of New Brunswick, P. O. Box 4400, Fredricton, NB E3B 5A3, Canada and complexity with a minimum number of synthetic steps for creation of highly functionalized molecules with interesting properties [1–4]. One approach to address this challenge involves the development of eco-friendly multi- component procedures. Within the last decade, multi-com- ponent reactions (MCRs) have been investigated exten- sively in organic and diversity-oriented synthesis mainly because of their convergent nature, superior atom economy,