18–22 September 2011, Los Angeles, CA, USA Poster abstracts Methods: In a prospective longitudinal study, during the routine first trimester assessment, we measured the FMF angle accordingly to the Fetal Medicine Foundation Guidelines. The data will be statistically analyzed to determine the significance of the difference between the previous European studies and ours. Results: The measurings were obtained in 49 of the first 50 cases (98%). The ethnic origin of the mothers was 42% caucasian, 22% blacks, 2% oriental and 34% of mixed races. The mean FMF angle decreased with crown–rump length (CRL) from 75o. at CRL 47.5 to 50 mm to 75o. at CRL 74 to 78.5 mm in all races. Conclusions: Apparently, the FMF angle can be applied with success to the Brazilian population. Further studies will include more patients in the analysis, meaning an increase of the significance of this data. P06.14 Normogram for frontomaxillary facial angle in a Lebanese population R. S. Abu-Rustum 1 , M. Ziade 2 , S. Abu-Rustum 3 1 Center For Advanced Fetal Care, Tripoli, Lebanon; 2 Public Health, Lebanese University, Tripoli, Lebanon; 3 Ob/Gyn, Nini Hospital, Tripoli, Lebanon Objectives: The frontomaxillary facial angle (FMFA) is a first trimester (FT) marker for trisomy. Recently, its role as a FT marker for spina bifida (SB) has been evaluated. Our objective was to determine the normogram for the FMFA in an unselected low risk Lebanese population and to compare our results to the established normogram of Borenstein et al to assess for any ethnic variations precluding its application in our population as an early FT marker of trisomy and SB. Methods: Prospective study on 361 fetuses with confirmed dating undergoing a FT scan at 11 to 14 weeks. All scans were performed by a single sonologist certified by the Fetal Medicine Foundation. The FMFA was measured in all fetuses in a mid sagittal plane according to the guidelines of the Fetal Medicine Foundation. Regression analysis was used to establish the relationship between fetal crown rump length (CRL) and FMFA. ANOVA test of means was employed to compare the mean FMFA in relation to the CRL. All fetuses were healthy term live births. Results: A total of 361 patients were included in the analysis. Mean CRL was 72.48 mm. Mean FMFA was 77.29 ◦ . Regression analysis was employed to establish the relationship of FMFA to CRL and it revealed no significant decrease in the FMFA with advancing gestation (P = 0.609) as has previously been described by Borenstein et al. Statistical analysis using ANOVA test of means comparing the mean FMFA with CRL indicated that the mean FMFA is significantly unchanged as CRL increases or decreases. For a CRL of 50–59, 60–69, 70–79 and 80–89 mm, the mean FMFA was 79.3 ◦ , 77 ◦ , 77 ◦ , 78.1 ◦ and 77.3 ◦ respectively (P = 0.421). The FMFA was > 85 ◦ in 7.8% of our patients. Conclusions: Our study demonstrates that in an unselected low risk Lebanese population, there is no statistically significant decrease in the FMFA with advancing gestation as has been previously reported by Borenstein et al. In 7.8% of our population, the FMFA is > 85 ◦ . This ethnic variation calls for employing caution when using the FMFA in our FT screening for trisomy and when screening fetuses who may be at risk for SB. P06.15 The nuchal translucency examination leading to early diagnosis of structural fetal anomalies I. Solt 1,2 , I. Goldstein 1,2 , B. Weizman 1 , K. Nizar 1 , Z. Weiner 1,2 1 Obstetrics & Gynecology, Rambam, Health Care Campus, Haifa, Israel; 2 Technion Faculty of Medicine, Haifa, Israel Objectives: To summarize five years experience of diagnosing structural fetal anomalies during an extended nuchal translucency (NT) examination. Methods: The study population included all women who had a routine NT examination in the ultrasound division of one of three centers. The sonographers were instructed to perform an extended NT examination by paying attention to fetal anomalies. Each examination was initially attempted transabdominally. Failure to obtain adequate views transabdominally was an indication for a transvaginal examination. When a structural fetal anomaly was detected or suspected, a full fetal anomaly scan was performed. When diagnosis could not be established, fetal anatomy scan was repeated after 14 weeks’ gestation. When fetal anomalies were diagnosed the patients were informed about the possibilities of terminating the pregnancy or continuing the work-up and follow-up. Overall, ascertainment of fetal outcome was available in 95% of the study population. Results: We performed 5321 NT examinations during the study period (2005–2010). The fetal anomalies detected included the following: five skeletal anomalies, nine brain anomalies, six urinary system anomalies, six abdominal anomalies, and two facial anomalies. Twelve of 28 patients chose to discontinue the pregnancy shortly following detection of the congenital anomaly (within 14 weeks’ gestation) and 11 patients waited for a repeated confirmatory scan to establish the diagnosis. Additional 29 non cardiac structural fetal anomalies were detected following the anatomy scan performed at 14–16 or 22–24 weeks’ gestation. Conclusions: The opportunity to diagnose structural fetal anomalies in early pregnancy, justifies the approach of extended NT examination. P06.16 Sensitivity of the 11–14 week scan in identifying structural abnormalities in a single centre in South India I. Suresh , S. Sairam, J. Ramesh, B. Kugan, V. Raja, S. Seshadri Mediscan, Chennai, India Objectives: To assess the sensitivity of detection of structural abnormalities at the 11–14 week scan in a large tertiary referral centre in South India. Methods: This was a retrospective study looking at the abnormalities identified in the first trimester scan between January 2008 and December 2010. Only those women with singleton pregnancies at the 11–14 weeks scan were included. The overall number of the structural abnormalities identified in the first and second trimester scans were analysed. The sensitivity of the first trimester was derived from this data. The abnormalities were categorized based on the system affected. Results: During the study period, 17,754 women underwent the 11–14 week scan. 197 (1.1%) structural abnormalities were identified in this group. 12932 woman returned for second trimester scans and in this group 190 (1.5%) structural abnormalities were identified in this group. Out of a total of 387 structural abnormalities, 51% of the abnormalities were detected by the first trimester scan. Cardiovascular (23%) and central nervous system (22%) abnormalities were the leading groups in the anomalies missed in the first trimester, followed by skeletal (19%) and gastro-intestinal abnormalities (18%). An audit of the missed abnormalities will also be presented. Ultrasound in Obstetrics & Gynecology 2011; 38 (Suppl. 1): 168–281 187