Please cite this article in press as: Soltani S, et al. FLG single nucleotide polymorphisms in chronic idiopathic urticaria. Allergol Immunopathol (Madr). 2015. http://dx.doi.org/10.1016/j.aller.2015.09.002 ARTICLE IN PRESS +Model ALLER-722; No. of Pages 5 Allergol Immunopathol (Madr). 2015;xxx(xx):xxx---xxx www.elsevier.es/ai Allergologia et immunopathologia Sociedad Espa ˜ nola de Inmunolog´ ıa Cl´ ınica, Alergolog´ ıa y Asma Pedi ´ atrica ORIGINAL ARTICLE FLG single nucleotide polymorphisms in chronic idiopathic urticaria S. Soltani a , A. Saghazadeh a , M. Movahedi b , M. Tavakol c , M. Sadr a , E. Farhadi d , N. Rezaei a,e,f,* a Molecular Immunology Research Center, School of Medicine,Tehran University of Medical Sciences, Tehran, Iran b Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran c Department of Allergy and Clinical Immunology, Shahid Bahonar Hospital, Alborz University of Medical Sciences, Karaj, Iran d Hematology Department, School of Allied Medical Science, Iran University of Medical Sciences, Tehran, Iran e Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran f Universal Scientific Education and Research Network (USERN), Tehran, Iran Received 9 July 2015; accepted 30 September 2015 KEYWORDS FLG; Filaggrin; SNP; Single nucleotide polymorphism; Chronic idiopathic urticaria Abstract Background: Filaggrin (FLG), which is formed from profilaggrin protein during epidermal termi- nal differentiation, is a prerequisite to squame biogenesis and thus for perfect formation of the skin barrier. Yet, the relationship between genetic polymorphisms of FLG and chronic idiopathic urticaria (CIU) has not been investigated. Methods: The study population consisted of 93 CIU patients and 93 healthy control subjects without a history of allergic, autoimmune or any other systemic disease. Five single nucleotide polymorphisms (SNPs) of FLG were investigated: rs2485518, rs3126065, rs2786680, rs3814300, and rs3814299. Results: For all the investigated polymorphisms, 100% of both CIU patients and control subjects exhibited one given allele and consequently one given genotype as following: A/A genotype for two SNPs, rs3126065 and rs2786680, C/C genotype for two SNPs, rs2485518 and rs3814300, and G/G genotype for one SNP rs3814299 of FLG, and hence no association was found between either allele frequencies or genotype distributions of FLG SNPs and CIU in an Iranian population. Conclusions: The present study examined the possible relationship between SNPs of FLG and CIU for the first time, and demonstrated that none of five investigated SNPs (rs2485518, rs3126065, rs2786680, rs3814300, and rs3814299) are correlated with CIU in an Iranian population. Further investigations are required to address whether ethnicity/race impacts on relationship between SNPs of FLG and CIU. © 2015 SEICAP. Published by Elsevier España, S.L.U. All rights reserved. ∗ Corresponding author. E-mail address: rezaei nima@tums.ac.ir (N. Rezaei). http://dx.doi.org/10.1016/j.aller.2015.09.002 0301-0546/© 2015 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.