S-1 Supporting Information Design, synthesis and biological evaluation of nonsteroidal cycloalkane[d]isoxazole-containing androgen receptor modulators Pekka K. Poutiainen, † Tuomas Oravilahti, ‡ Mikael Peräkylä, ‡ Jorma J. Palvimo, ‡ Janne A. Ihalainen, § Reino Laatikainen, † and Juha T. Pulkkinen,* ,† † School of Pharmacy and ‡ Institute of Biomedicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland § Nanoscience Center, Department of Biological and Environmental Sciences, University of Jyväskylä, P.O. Box 35, FI-40014 University of Jyväskylä, Finland AUTHOR INFORMATION. To whom correspondence should be addressed. Juha T. Pulkkinen, School of Pharmacy, University of Eastern Finland, P. O. Box 1627, FI-70211, Finland. Phone: +358-40-3553247. Fax: +358-17-163259. E-mail: juha.t.pulkkinen@uef.fi. S-1 Title page S-2-6 Figures S1-S5 S-7-10 Tables S1-S4