1 TITLE: Xyloglucan, hibiscus and propolis for the prevention of urinary tract 1 infections. Results of in vitro studies 2 3 SHORT TITLE: A medical device for the prevention of UTIs 4 5 AUTHORS: Benito Fraile (1)*, Javier Alcover (2)*, Mar Royuela (1), David 6 Rodríguez (2), Concepción Chaves (1), Ricardo Palacios (2), Núria Piqué (3) 7 *Both authors equally contributed 8 9 AFFILIATIONS OF ALL AUTHORS: 10 1: Department of Biomedicine and Biotechnology, University of Alcalá, 28871, Alcalá 11 de Henares, Madrid, Spain. 12 2: Laboratorios DIATER, SA. Avenida Gregorio Peces Barba, nº 2. Parque Tecnológico 13 de Leganés. 208918 Leganés, Madrid, Spain. 14 3: Department of Microbiology and Parasitology, Pharmacy Faculty, Universitat de 15 Barcelona (UB), Diagonal Sud, Facultat de Farmàcia, Edifici A, Av Joan XXIII, 08028 16 Barcelona, Spain. 17 18 FUNDING: The study was supported financially by Novintethical Pharma, SA, 19 Switzerland. 20