MSM vs. 6.4% HSM, p<.0001). In terms of treatment choices, HSM
were more likely to undergo surgery (57.5% vs. 33%, p<.01), MSM
were more likely to opt for radiation (47.6% vs. 14.9%, p<.05) and both
groups were equally likely to choose active surveillance (14.9%
vs. 16.7%).
CONCLUSIONS: Our study shows no differences in what men
with PCa find to be important when choosing PCa treatment by sexual
orientation. No differences were seen perceptions or bother associated
with common side effects of treatment. Despite this, more MSM appear
to be choosing radiation therapy over surgery. A majority of MSM felt
that there is a dearth of information on the impact of PCa treatment on
their quality of life (QoL). Together, this highlights the need to offer MSM
more information on side effect profiles of different PCa treatments with
data on how each type of treatment impacts QoL, so that all men may
make an informed decision when choosing treatment.
Source of Funding: none
PD40-10
THE FRAGILITY INDEX OF RANDOMIZED CONTROLLED
TRIALS IN THE FIELD OF UROLOGICAL ONCOLOGY-
A SYSTEMIC REVIEW
Leon Chertin, Amnon Zisman, Miki Haifler*, Zerifin, Israel
INTRODUCTION AND OBJECTIVE: RCT's provide high quality
evidence upon which clinical guidelines are based. The use of p values
to estimate statistical significance of findings is subject to significant
control. In order to assess the robustness of RCTs a novel metric known
as the fragility index (FI) has been developed. The FI is defined as the
minimum number of events in a trial who must “shift” from the inter-
vention to the control group so that the trial statistical result becomes
non-significant. We previously reported the fragility in the field of
urological oncology. Our aim is to evaluate the fragility in urological
oncological RCTs following a systemic review.
METHODS: The systematic review was reported according to
the Preferred Reporting Items for Systematic Reviews and Meta-
analysis (PRISMA). All RCTs with 2 arms and at least one binary
outcome in 5 major urologic journals were identified in MEDLINE and
EMBASE databases from 2016-2019. Two authors collected data
including journal name, publication year, outcome, number of
randomized patients, number of events and total patients in control
and intervention arm, number of patients lost to follow-up, type of
outcome (primary/secondary), p value. The risk of bias was calculated
with Cochrane risk-of-bias tool. Correlation between FI, FQ and
sample size, p value was examined with Spearman's correlation
coefficient. Kruskal-Wallis test was used to examine the distribution of
FI or FQ across categorical variables. All analyses were performed
using R software.
RESULTS: 40 studies met our inclusion criteria and 81 primary
dichotomous outcomes were assessed. The median sample size and p
value of RCTs were 199 (IQR 113,620) and 0.4 (IQR 0.05,0.61)
respectively. The primary outcome was found to be statistically signifi-
cant in 29/81 of RCT (36%).The median FI for the included 40 trials was
4 cases (IQR 3,7). The median FI for the primary and secondary out-
comes was 5 (IQR 3,8) and 3 (IQR 3,6) respectively (p[0.2). In 24/40
cases (61.7%) the FI was larger than the total number of patients lost to
follow up. There was a modest correlation between the fragility index
and the sample size (ms 0.50, p<0.01). No correlation was found be-
tween the fragility index the p value, ROB groups, study positivity, type
of outcome and number of patients lost to follow up.
CONCLUSIONS: The results of urological oncological RCTs
are sometimes fragile and depend on few events. Considering reporting
the fragility index alongside p values may better utilize the results
published in RCTs in the field of urological oncology.
Source of Funding: No Funding
PD40-11
URINARY INCONTINENCE CARE FOR OLDER ADULTS:
DIFFERENCE OR DISPARITY?
Claire S. Burton*, Los Angeles, CA; Jennifer Tran, Mount Pleasant, MI;
Gabriela Gonzalez, Catherine Bresee, Eunice Choi,
Victoria Scott, A. Lenore Ackerman, Karyn S. Eilber, Jennifer T. Anger,
Los Angeles, CA
INTRODUCTION AND OBJECTIVE: Urinary incontinence (UI)
has a significant burden on health care costs, particularly among the
elderly. Assessing Care of Vulnerable Elders-2 (ACOVE-2) found that
overall quality of care for vulnerable elders is inadequate. We sought
to evaluate the care surrounding UI provided by primary care
providers (PCPs) prior to referral to a specialist, and to determine
whether UI is treated differently in elderly (75) vs younger (<75)
female patients.
METHODS: A sample of 247 women consecutively referred for
new or worsening bothersome UI to a single-center FPMRS group
practice between March 2017 and May 2018 was identified. Using a
set of 12 previously developed Quality of Care Indicators (QIs), we
measured the care provided by PCPs in the 12-month period prior to
the first visit with an FPMRS specialist. The QIs for UI have been
previously validated and include elements from the patient history,
physical examination, urinalysis, recommended behavioral
interventions, and pharmacologic treatment.
RESULTS: For women 75 years of age, PCPs were less
likely to take a focused history differentiating between stress and urge
incontinence (55% vs 77%, p<0.05) or do a pelvic exam (26% vs 50%,
p<0.01) when compared to their younger counterparts. Yet providers
were more likely to take a history of prior pharmaceutical treatment
(28% vs 10%, p<0.01) and obtain a urinalysis or urine culture (74% vs
57%, p<0.05) for older women. Rates of management initiation were
low in both groups, with only 30% of PCPs offering behavioral man-
agement (Table).
CONCLUSIONS: We found generally low rates of QI compli-
ance by PCPs, with older female patients receiving significantly worse
care. Low rates of pelvic exams may be due to the fact that women over
75 no longer require routine pelvic exams per the USPSTF recom-
mendations. On the other hand, urinalyses were more frequently ob-
tained, possibly due to an increased incidence in this age group.
Improvement of UI care at the primary care level for older female pa-
tients could significantly reduce healthcare costs and improve practical
interventions aimed at improving care for geriatric conditions,
including UI.
Source of Funding: 1R56DK117261-01
PD40-12
THE BURDEN OF PATIENT COMMUNICATION OUTSIDE THE EXAM
ROOM IN AN INFERTILITY PRACTICE
Jagan K. Kansal*, John Doolittle, Peter N. Dietrich, Vimal Gunasekaran,
Zachary J. Prebay, Robert Medairos, Jay I. Sandlow, Milwaukee, WI
INTRODUCTION AND OBJECTIVE: Physician burnout has
been attributed to an increase in administrative tasks. Patient questions
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