Indian Journal of Pathology and Oncology 2021;8(2):320–326 Content available at: https://www.ipinnovative.com/open-access-journals Indian Journal of Pathology and Oncology Journal homepage: www.ijpo.co.in Original Research Article Role of imprint cytology in the diagnosis of ovarian neoplasms Archana Shivamurthy 1, *, Padmapriya Jaiprakash 2 1 Dept. of Pathology, JSS Medical College, Mysore, Karnataka, India 2 Dept. of Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka ARTICLE INFO Article history: Received 19-06-2021 Accepted 30-06-2021 Available online 12-08-2021 Keywords: Imprint Cytology Ovary Tumors ABSTRACT Primary ovarian neoplasms constitute a heterogenous group of benign and malignant tumors of epithelial, sex cord–stromal, mesenchymal and germ cell origin. Secondary tumors constitute a minority. The management of benign and malignant ovarian neoplasms varies and it is here that imprint cytology plays a crucial role in diagnosis. It provides a rapid intraoperative diagnosis which will decide further treatment course for the patient. Imprint cytology of ovarian neoplasms is simple, inexpensive, challenging and provides a rapid diagnosis with excellent cellular details. The aim of the present study is to determine the role of imprint cytology in the diagnosis of ovarian neoplasms. A retrospective study was conducted in the department of pathology. A total of 53 cases were included in the study. In 48 cases, the imprint cytology findings correlated with the histopathological diagnosis. 5 cases did not correlate. Epithelial ovarian tumors accounted for the majority, (85%) followed by germ cell tumors (9.4%) and sex cord stromal tumors (5.6%). The sensitivity and specificity were 93.75% and 100% respectively. Thus imprint cytology is an effective cytological method in the diagnosis of ovarian neoplasms. Knowledge of specific cytological features for each tumor type helps in accurate diagnosis which in turn is valuable in immediate appropriate treatment and management of patients with benign or malignant neoplasms. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: reprint@ipinnovative.com 1. Introduction Ovarian neoplasms are a diverse group of tumors which exhibit a spectrum of morphological characteristics, clinical manifestations, genetic alterations, and tumor behaviors. This high degree of variability presents a major challenge in both diagnosis and treatment. Imprint cytology provides a rapid intraoperative diagnosis which will decide further treatment course for the patient. 1–5 It is a simple, inexpensive, challenging and provides a rapid diagnosis with excellent cellular details. Knowledge of both cytological and histopathological features plays a crucial role in accurate diagnosis, which in turn affects patient management. An accurate final histological * Corresponding author. E-mail address: archana_018@yahoo.co.in (A. Shivamurthy). diagnosis is important owing to the major differences in incidence, tumor behavior and clinical outcome between each histologic subtype. 6–11 Hence the aim of the present study is to determine the role of imprint cytology in the diagnosis of ovarian neoplasms 2. Materials and Methods A retrospective study was conducted at the department of pathology from January 2011 to December 2015 for a period of five years. A total of 53 cases were included in the study. Imprint cytology smears stained with hematoxylin and eosin (H & E) were reviewed along with respective frozen sections and routine histopathology slides. Imprint cytology slides and scrape smears were made immediately from representative solid areas on cut section of the ovarian https://doi.org/10.18231/j.ijpo.2021.064 2394-6784/© 2021 Innovative Publication, All rights reserved. 320