Chem Sci Trans., 2013, 2(4), 1089-1093 Chemical Science Transactions DOI:10.7598/cst2013.301 ISSN/E-ISSN: 2278-3458/2278-3318 Design, Synthesis and Pharmacological Evaluation of New Series of Pyrazolines Based Thiazolidin-4-one Derivatives PINKA PATEL, DEEPA GOR and P. S. PATEL * K. K Shah Jarodwala Maninagar Science College, Ahmedabad-8, India * Department of Chemistry, Sheth L. H. Science College, Mansa-382845, India pinkapatel59@yahoo.in Received 11 July 2012 / Accepted 16 August 2012 Abstract: We have prepared 2-{4-[2-{5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-pyrazol-1- yl}-2-oxoethoxy]phenyl}-3-(substituted phenyl)-1,3-thiazolidin-4-one form N-[{4-[2-{5-(4-chloro- phenyl)-3-(4-methoxyphenyl)-4,5-dihydro-pyrazol-1-yl}-2-oxoethoxy]phenyl}methylene] substituted aniline and thioglycolic acid. Compound having an excellent properties regarding as per as anti cancer and HIV as compared to this compound. Physical properties of pure crystallized substance of 2-{4-[2- {5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-pyrazol-1-yl}-2-oxoethoxy]phenyl}-3-(subs- tituted-phenyl)-1,3-thiazolidin-4-one substituted aniline like M.P elementary analysis and spectral data of compound and such as IR and NMR will be evaluated and confirm the structure of compound. All the synthesized products were evaluated for their antimicrobial activity. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method. Keywords: Synthesis, Pyrazoline, Chalcones, Schiff base, DMSO, Antimicrobial activity Introduction Thiazolidinones are the derivatives of thiazolidine which belong to an important group of heterocyclic compounds containing sulfur and nitrogen in a five member ring. 4-Thiazolidinones 1 have attracted considerable attention as they are endowed with wide range of pharmaceutical activities. The nucleus is also known as wonder nucleus because it gives out different derivatives with all different types of biological activities. One of the main objectives of organic and medicinal chemistry is the design, synthesis and production of molecules having value as human therapeutic agents. During the past decade development in the field of combinatorial chemistry has provided access to chemical libraries based on privileged structures 2 . 4-Thiazolidinones are associated with anticancer 3 and versatile pharmacological activities 4,5 like anti-tubercular 6 anti–inflammatory 7 antimicrobial 8 , anti – RESEARCH ARTICLE