Gaur S et al JMSCR Volume 04 Issue 08 August Page 12139 JMSCR Vol||04||Issue||08||Page 12139-12145||August 2016 Evaluation of Adverse Drug Reactions in teaching hospital in Kumoun Region Authors Gaur S 1 , Paramjeet S 2 , Srivastava B 3 , Bhardwaj R 4 , Ahuja S 5 , Gunjita B. 6 1,4 Associate Professor, Department of Pharmacology GMC Haldwani 2 Associate Professor Department of Medicine GMC Haldwani 3 Professor, Department of Pharmacology GMC Haldwani 5 Assistant Professor, Department of Pharmacology GMC Haldwani 6 Technical Associate Department of Pharmacology GMC Haldwani Corresponding Author Dr Sanjay Gaur Associate Professor, Dept of Pharmacology, Government Medical College Haldwani. Nainital Uttarakhand Email: gaursanjay75@gmail.com Abstract Objective: The main aim of the study was to assess the occurrence and pattern of ADR S , assess causality and documentation of Suspected ADR S, inteaching hospital in Kumoun Region. Methods: It is a retrospective study about the occurence, nature, pattern and outcome of ADR monitoring from Aug 2015 to July 2016. The ADR S were assessed for casualty using world health organization (WHO) casualty assessment Scale and Naranjo’s algorithm. Result: 466 ADR S were recorded from 251 ADRs form, Male: Female ratio was 1:1.6. Antibiotics / Antimicrobial (32.06%) followed by Anti-viral (23.76%), Anti-tubercular (19.50%) and NSAIDS (6.05%). The common drugs causing ADR were Albendazole 15.24%, Duloutine 8.52%, Pyrizenamide 6.95%, and Metronidazole 4.48%. The most common system involved were gastro intestinal tract 31.16% of ADR, followed by central and peripheral nervous system 27.35%, skin and appendages 22.42% and hormonal system 8.07%. Out of the total ADRs, 62% were possible, 30% were probable 2% were certain and 6% were uncertain. 60.08% of the ADRs were moderate intensity 34.97% were mild and 4.93% of ADRs were severe Conclusion: ADRs are one of the commonest and important cause of mortality and mortality. There is need for greater awareness among doctors health care workers so that it can be minimized and managed. Keywords: Adverse drug Reactions, causality Naranjo’s scale. Introduction Adverse drug Reaction (ADRs) cause a sizeable part of overall morbidity and mortality with increase in medical expenses. ADRs have been defined by the World health organization (WHO) as “any response to a drug which is noxious and unintended and which occurs at doses normally used in man for prophylaxis, diagnosis or therapy of disease, or for the modification of physiological function . [1] Considering the importance of monitoring ADRs for improving public health, Pharmacovigilance programme of India (PvPI) www.jmscr.igmpublication.org Impact Factor 5.244 Index Copernicus Value: 83.27 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: http://dx.doi.org/10.18535/jmscr/v4i8.76