Int. J. Pharm. Investigation, 2021; 11(3) : 260-268 International Journal of Pharmaceutical Investigation, Vol 11, Issue 3, Jul-Sep, 2021 260 Review Article INTRODUCTION Sprays can be in the form of coarse droplets or eventually divided solids of aqueous or oleaginous solution that will be sprayed topically and to the nasal pharyngeal tract, and these suspensions and solutions will be poured into spraying bottles. Te therapeutic agent and various types of excipients are dissolved in a suitable solvent in the pharmaceutical solution. Te solution delivered the medicine to the target spot by gently pressing the spray container against the skin and activating the discharge of the spray. Te medication spreads throughout the skin’s surface before being absorbed. According to the literature, topical sprays contain the following ingredients: medicament, flm forming, carrier, penetration enhancer, solublizer, plasticizer, and water-soluble additive. Topical spray medication compositions like antiseptics, germicides, and anaesthetics are available on the market. Te spray particles delivered by topical spray are bigger than those delivered by nasal spray. When sprayed on the skin, the composition must generate a breathable, stable flm across a specifc surface area. 1 Te liquid droplets, solid particles, or carrier gas in a pressurized topical spray (aerosol pharmaceutical) are compressed or liquefed under pressure in the container. When the pressure in the container drops, the ingredient is delivered to the application place as fne solid particles and liquid mist. Value assembly, gasket, propellant, actuator, stem, spring, housing, mounting cup, and dip tube are some of the components of an aerosol spray container. 2 Aim and objective of review article to provide topical spray products pharmaceutical lifecycle management data ofers regulatory bodies with a signifcant fnancial beneft. Topical non-pressurized sprays have been developed for a variety of applications due to their ease of use, environ- mental friendliness, low cost, and innovative technology. METHODOLOGY OF MANAGEMENT OF TOPICAL SPRAY Design, defne, development, composition, dosage form, pharmacology, indication, administration, dosage, contraindication, strength, assay, content uniformity, quality, undesirable efect, over dosage, specifcation, container closure system, labelling, miscellaneous changes, packaging information, and more are all aspects of topical spray lifecycle management. Topical spray drug products contain a solution of the medicine plus an excipient in a spray bottle. Te active material is equally distributed across the skin’s surface area by the spray bottle. Te paper contains details on the chemistry, manufacturing, and documentation that should be included in a New Drug Application (NDA) or Abbreviated New Drug Application (ANDA) for a topical spray with local and systemic efects. Product lifecycle management has enabled products to be quickly sold with minimal development costs and excellent regulatory compliance in today’s world. 3 Formulation Components Te product concentration, which is the active medication, is coupled with extra excipient in the spray formulation. Each formulation component should be identifed by the name given by the International Union of Non-Pressurized Topical Spray Pharmaceutical-Methodology of Formulation Development and Quality Control Management Neelam Pawar*, Pawan Jalwal Department of Pharmaceutical Sciences, Baba Mastnath University, Asthal Bohar, Rohtak, Haryana, INDIA. ABSTRACT The medicine was given to the target site with a pressurized topical spray (aerosol pharmaceutical) and a non-pressurized topical spray solution by gently pressing the spray container against the skin and initiating the spray. Formulation components consists of product concentrate (one or more pharmaceutical drugs with relevant excipient) and packaging components (valves, pump, actuator, container). After formulation process development various quality control test like spray pattern, spray content uniformity and geometry, particulate matter, droplet size distribution, microbial limit, net content, pH, osmolarity, weight loss, leachability, viscosity, valves, actuators, diptubes, weight checking, leak test, valve discharge rate, dosage with valves, therapeutic activity, and toxicity studies to check the quality and ef fcacy. The beneft of Topical Spray Life Cycle Management (post-approval adjustments, 30-day supplements, annual report, Food and Drug Administration inspection and enforcement, cover letter, risk management standard and related information from the International Organization for Standardization) is that it covers the entire lifecycle of a topical spray, from conception through formulation design development to marketing. The product lifecycle management data offers regulatory bodies with a signifcant fnancial beneft. Topical non-pressurized sprays have been developed for a variety of applications due to their ease of use, environmental friendliness, low cost, and innovative technology. This review give details about meter dose topical spray of Estradiol, 1% tolnaftate, 2% Miconazole nitrate spray, 0.5% w/w Voriconazole spray, Clotrimazole transdermal apray, Lopinavir meter dose transdermal spray are studied by researcher. This review also enlisted patents and marketed formulation on topical spray from year 2007 to 2020. Key words: Non-pressurized topical spray, Lifecycle management, Scale up and post approval changes, Quality control, Valve Components. Correspondence Ms. Neelam Pawar, Department of Pharmaceutical Sciences, Baba Mastnath University, Asthal Bohar, Rohtak-124021, Haryana, INDIA. Email id: neelampawar5555@gmail.com DOI: 10.5530/ijpi.2021.3.46 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.