International Journal of Research in Dermatology | July-August 2021 | Vol 7 | Issue 4 Page 538 International Journal of Research in Dermatology Nijhawan M et al. Int J Res Dermatol. 2021 Jul;7(4):538-542 http://www.ijord.com Original Research Article Clinicopathological correlation in the diagnosis of granulomatous cutaneous disorders: a retrospective study Manisha Nijhawan, Divya Yadav*, Shivi Nijhawan, Damini Shaktawat INTRODUCTION ‘Granuloma’ is defined as a focal chronic inflammatory response to tissue injury characterized by a collection of activated histiocytes, epithelioid cells with variable numbers of admixed multinucleated giant cells and inflammatory cells that may or may not be rimmed by lymphocytes and or show central necrosis. Virchow described the term “granulomatous” as a tumor-like mass or nodule of granulation tissue. 1,2 Granulomatous disorders are a diagnostic challenge to dermatologists due to similar histological features and varied clinical presentations. Therefore, clinic-histopathological correlation of granulomatous disease plays a pivotal role in diagnosis. In Dermatology skin biopsy is often considered as confirmatory in case of diagnostic dilemma and is the most common investigation sought by a dermatologist. Dermascopy is also used as diagnostic tool but skin biopsy is considered as gold standard investigation. The aim of this study was to determine the relative indications of skin biopsies in granulomatous groups of skin disorders and to evaluate the clinicopathological consistency in diagnosis of granulomatous skin disorders. The objective of the study is to correlate clinical and histopathological features of granulomatous skin disorder to arrive at a conclusive diagnosis. METHODS This was a retrospective study over a period of three years at a tertiary care centre in Jaipur. Total number of ABSTRACT Background: To ascertain the various cutaneous granulomatous disorders and clinicopathological concordance in skin biopsies. Methods: The study included the patients with skin biopsy showing granulomatous infiltrate in a tertiary care center. The cases were categorized according to level of concordance into consistent, corroborative and inconsistent based on the concurrence between clinical and histological diagnosis. Results: Of the total 155 granulomatous disorder, 75.48% showed clinicopathological concordance, 19.35% showed corroborative diagnosis while 5.16% were inconsistent. The maximum number of biopsies performed were in the group of young adult (19-49 years, 57.41%). The most common type of granuloma found was of tuberculoid type and disorders were Hansen’s disease, fungal infection and cutaneous tuberculosis. Conclusions: Our study showed that the coordination of dermatologist and pathologist plays a pivotal role in making accurate diagnosis of granulomatous cutaneous dermatoses. Keywords: Biopsy, Clinicopathological correlation, Granuloma DOI: https://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20212549 Department of Dermatology, Mahatma Gandhi medical college, jaipur, Rajasthan, India Received: 28 May 2021 Accepted: 16 June 2021 *Correspondence: Dr. Divya Yadav, E-mail: rockin.diva3@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.