1 Submitted to Genome Research 05/28/02 Testing of a novel ultra-sensitive DNA sequencing instrument based on single photon detection. O. Bilenko 1 , D. Gavrilov, B. Gorbovitski 1 , M. Gouzman, G. Gudkov, O. Kosobokova, N. Lifshitz 1 , S. Luryi, A. Stepoukhovitch, M. Tcherevishnick, G. Tyshko, V. Gorfinkel Department of Electrical and Computer Engineering, SUNY SB, Stony Brook, NY V. Balija, A. Bahret, R. Shah, L. King, L. Speigel, W.R. McCombie Cold Spring Harbor Laboratory, Woodbury Genome Center, Cold Spring Harbor, NY Key words: DNA sequencing instrument, single photon detection, To whom correspondence should be addressed: Prof. Vera Gorfinkel Phone: (631) 751-87-38 Fax: (631) 751-24-57 E-mail: vera@ece.sunysb.edu 1 BioPhotonics Corporation, NY