ORIENTAL JOURNAL OF CHEMISTRY www.orientjchem.org ISSN: 0970-020 X CODEN: OJCHEG 2012, Vol. 28, No. (1): Pg. 409-412 Est. 1984 An International Open Free Access, Peer Reviewed Research Journal A Novel Synthesis and Antimicrobial Studies of 3-(4-Substitutedthiocarbamidophenyl)-N, N-dimethyl-3-Pyridin-2-yl-propan-1-amine.p DIPAK TAYADE 1 , RUPESH SHEKAR 2 and RAHIM SHEKAR 1 1 Department of Chemistry, Mahatma Fule Arts & Commerce & Sitaramji Chaudhri Science Mahavidyalya Warud, Amravati (M.S.) Pin code 444 906 (India). 2 Dept. of chemistry, Government, V.I.S.H, Amravati, 444 604 (India). Email: - skdtayade@gmail.com , shekar.rupesh@gmail.com (Received: April 12, 2012; Accepted: June 04, 2012) ABSTRACT Heteroacyclic and Heterocyclic containing drugs showed remarkable and noticeable drug absorption, transmission and drug effects; hence they created their own identity and importance in pharmaceutical, medicinal, agricultural and drug sciences. Thioamido and benzamido heterocyclic compounds showed various significances and applications in industrial, pharmaceutical, medicinal and drug chemistry. Considering all these facts into consideration it was thought interesting to synthesize 3-(4-substitutedthiocarbamidophenyl)-N, N-dimethyl-3-pyridin-2-yl-propan-1-amine by interacting 3-(4-chlorophenyl)-N, N-dimethyl-3-pyridin-2-yl-propan-1-amine with various thiourea in isopropanol medium .The justification and identification of the structure of these newly synthesized compounds had been established on the basis of chemical characterization, elemental analysis, and through spectral data . Key words: Substitutedthiocarbamides, 3-(4-substitutedthiocarbamidophenyl)-N, N-dimethyl-3-pyridin-2-yl-propan-1-amine and isopropanol INTRODUCTION Recently in this laboratory the synthetic applications of cynoguanidine and 1, 3- diformamido-thiocarbamide had been briefly explored 1 . As evident from structure of 3-(4- substituted thiocarbamidophenyl)-N, N-dimethyl-3- pyridin-2-yl-propan-1-amine, it possesses chloro, amino, methyl and ethyl reactive sites for various reactions. As a wider programmee of this laboratory in the synthesis of nitrogen, sulphur and nitrogen and sulphur containing heteroacycles and heterocycles the interactions of cynoguanidine with various thiourea and isothiocynates have been investigated in sufficient details 2-8 . Some of these compounds showed remarkable pharmaceutical and biological activities 9-12 . An exhaustive literature survey on thiocarbamids 3-6 and 3-(4-substituted thiocarbamido phenyl)-N, N-dimethyl-3-pyridin-2- yl-propan-1-amine 13-15 showed that these nucleus containing drugs play an important role in pharmaceutical, medicinal and drug chemistry having remarkable pharmaceutical, medicinal and biochemical applications, by considering all these facts into considerations interactions of 3-(4- chlorophenyl)-N, N-dimethyl-3-pyridin-2-yl-propan-