Int. J. Pharm. Sci. Rev. Res., 70(2), September - October 2021; Article No. 15, Pages: 126-143 ISSN 0976 – 044X International Journal of Pharmaceutical Sciences Review and Research Available online at www.globalresearchonline.net ©Copyright protected. Unauthorised republication, reproduction, distribution, dissemination and copying of this document in whole or in part is strictly prohibited. 126 Ranajit Nath 1* , Ambika Mandal 1, Ratul Bhowmik 2 , Ratna Roy 1 , Riya Biswas 3, Soubhik Bhattacharyya 1 1* NSHM Knowledge Campus, Kolkata- Group of Institutions, Kolkata, West Bengal, India. 2 Department of Pharmaceutical Chemistry, SPER, Jamia Hamdard, New Delhi, India. 5 Jadavpur University, Department of Pharmaceutical Technology, West Bengal, India. *Corresponding author’s E-mail: ranajitnath465@gmail.com Received: 18-07-2021; Revised: 23-09-2021; Accepted: 30-09-2021; Published on: 15-10-2021. ABSTRACT The infection that causes COVID-19 may be a pathogen referred to as severe acute respiratory syndrome coronavirus-2 (SARS-CoV- 2) and is believed to possess originated from China's Wuhan Province. The rapid spread of coronavirus disease 2019 (COVID-19) has become a worldwide concern, with the planet Health Organization (WHO) declaring it an epidemic on March, 2020. To enter the cells, SARS-CoV-2 S requires angiotensin-converting enzyme 2 (ACE2). Many existing vaccines have drawbacks like insufficient system stimulation, in vivo instability, high toxicity, the need for a chilly chain, and multiple administration. A nanotechnology is an efficient tool for addressing these issues. A successful vaccine against SARS-CoV-2 infection is predicted to stimulate innate and adaptive immune responses and protects against severe sorts of coronavirus disease 2019 (COVID-19). Different strategies are introduced because the go after an efficient and safe vaccination has begun. Currently, the foremost common vaccine types studied in clinical trials include viral vector-based vaccinations, genetic vaccines, attenuated vaccines, and protein-based vaccines. during this review, we cover the foremost promising anti-COVID-19 vaccine clinical trials also as various vaccination strategies to shed more light on the continued clinical trials. it's also discussed how nanotechnology is often wont to better understand the pathology of the present pandemic, also as how our understanding of SARS-CoV-2 cellular uptake and toxicity can influence future nanotoxicological considerations and nanomedicine design of safe yet effective nanomaterials. Keywords: Nano vaccine, COVID 19, strategies, clinical trial, drawbacks. QUICK RESPONSE CODE → DOI: 10.47583/ijpsrr.2021.v70i02.015 DOI link: http://dx.doi.org/10.47583/ijpsrr.2021.v70i02.015 INTRODUCTION he novel coronavirus which is now officially declared as severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2, is considered to be the main causative agent of that COVID-19 disease. The Wuhan city which is located in China was the first epicenter of this disease, but now more than 8.3 million cases have been reported. The particular word “coronavirus” is given because the club-shaped protein spikes are present on their upper surface when viewed under a special type of microscope which is known as transmission electron microscope (TEM). According to the genetic information, the virus is divided into four categories Alpha, Beta, Gamma, and Delta 26 of which the main causative agent behind all the COVID-19 pandemic situations belongs to the beta class 9 . Two types of regional epidemics are a middle east respiratory syndrome known as MERS and a severe acute respiratory syndrome known as SARS in 2012 to 2015 and 2001 to 2003, respectively . 6 The three months from the date of 30th January 2020, when the first COVID-19 case was recorded officially in India, we have found that there were over thousand and thousand deaths happened from that disease, which is now across 537 in the rest of South Asia. In this pandemic situation, India logged a huge amount of COVID-19 deaths than Ireland. Statistically found that from May 10, 2020, India had passed 2,000 death cases and therefore India was starting lockdown restrictions because it touched up to 180,000 death cases by the middle of June. 1 The direct transmission mode of this virus is happening via (1) aerosols, which is formed via dental procedures and surgical procedures or it can be transmitted in the form of respiratory droplet; (2) mother to her child (3) human secretions and discharge and body fluids, for example, urine, feces, semen, tears, and saliva. This virus is most commonly spread via respiratory droplets which formed while sneezing, talking, coughing of an infected person to other normal people. The risk of transmission will increase if a virus-infected person is present within a 1-meter diameter of another person. On the other way, Indirect transmission occurs via (1) surfaces of furniture and fixtures present within the immediate using environment of infected patients and (2) objects which are used by the infected person. 24 Epidemiological study shows that the symptoms of this disease are cough, fever, dyspnoea, accounting for 82%, 83%, and 31% of the COVID-19 patients respectively. A Pervasive Review on New Advancements of Nano Vaccines on Covid-19 Pandamic T Review Article