REVIEW published: 25 April 2022 doi: 10.3389/fped.2022.881765 Edited by: Sandra Trapani, Meyer Children’s Hospital, Italy Reviewed by: Saul Flores, Texas Children’s Hospital, United States Maria Teresa Terreri, Federal University of São Paulo, Brazil *Correspondence: Silvina Ruvinsky sruvinsky@garrahan.gov.ar † ORCID: Silvina Ruvinsky orcid.org/0000-0001-8729-1119 Rolando Ulloa-Gutierrez orcid.org/0000-0002-9157-9227 Ariel Bardach orcid.org/0000-0003-4437-0073 Specialty section: This article was submitted to General Pediatrics and Pediatric Emergency Care, a section of the journal Frontiers in Pediatrics Received: 23 February 2022 Accepted: 29 March 2022 Published: 25 April 2022 Citation: Ruvinsky S, Voto C, Roel M, Fustiñana A, Veliz N, Brizuela M, Rodriguez S, Ulloa-Gutierrez R and Bardach A (2022) Multisystem Inflammatory Syndrome Temporally Related to COVID-19 in Children From Latin America and the Caribbean Region: A Systematic Review With a Meta-Analysis of Data From Regional Surveillance Systems. Front. Pediatr. 10:881765. doi: 10.3389/fped.2022.881765 Multisystem Inflammatory Syndrome Temporally Related to COVID-19 in Children From Latin America and the Caribbean Region: A Systematic Review With a Meta-Analysis of Data From Regional Surveillance Systems Silvina Ruvinsky 1 * † , Carla Voto 1 , Macarena Roel 1 , Ana Fustiñana 2 , Natalia Veliz 3 , Martin Brizuela 4 , Susana Rodriguez 1 , Rolando Ulloa-Gutierrez 5† and Ariel Bardach 6† 1 Coordinación de Investigación Clínica y Sanitaria, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina, 2 Servicio de Emergencias, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina, 3 Área de Internación, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina, 4 Hospital General de Agudos “Vélez Sarsfield”, Ciudad Autónoma de Buenos Aires, Argentina, 5 Servicio de Infectología, Hospital Nacional de Niños Dr. Carlos Sáenz Herrrera, Caja Costarricense de Seguro Social & Universidad de Ciencias Médicas (UCIMED), San José, Costa Rica, 6 Center for Research in Epidemiology and Public Health, Institute for Clinical Effectiveness and Health Policy (IECS) and National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina Background: With the emergence of the COVID-19 pandemic, increasing numbers of cases of the multisystem inflammatory syndrome in children (MIS-C) have been reported worldwide; however, it is unclear whether this syndrome has a differential pattern in children from Latin America and the Caribbean (LAC). We conducted a systematic review and meta-analysis to analyze the epidemiological, clinical, and outcome characteristics of patients with MIS-C in LAC countries. Methods: A systematic literature search was conducted in the main electronic databases and scientific meetings from March 1, 2020, to June 30, 2021. Available reports on epidemiological surveillance of countries in the region during the same period were analyzed. Results: Of the 464 relevant studies identified, 23 were included with 592 patients with MIS-C from LAC. Mean age was 6.6 years (IQR, 6–7.4 years); 60% were male. The most common clinical manifestations were fever, rash, and conjunctival injection; 59% showed Kawasaki disease. Pool proportion of shock was 52%. A total of 47% of patients were admitted to the pediatric intensive care unit (PICU), 23% required mechanical ventilation, and 74% required vasoactive drugs. Intravenous gamma globulin alone was administered in 87% of patients, and in combination with steroids in 60% of Frontiers in Pediatrics | www.frontiersin.org 1 April 2022 | Volume 10 | Article 881765