International Journal of Advanced Research in Engineering and Applied Sciences ISSN: 2278-6252 Vol. 1 | No. 6 | December 2012 www.garph.co.uk IJAREAS | 31 STRUCTURE BASED DRUG DESIGNING ON BREAST CANCER GENE (BRCA 1) Rajeswara Reddy. Erva* Vijaya Kumar S** Abstract: Breast Cancer is the world’s second death causing disease. BRCA1 is the gene responsible for causing this Breast Cancer. Actual function of BRCA1 is to control the cell division at optimal levels. If there is any abnormality in the gene then the division of breast cells will be altered and as a result the cancerous growth of cells will occur in breast. BRCA1 codes for a protein of 1863 amino acids, producing a protein of about 220 kd. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1- associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Even though there are some drugs to cure this disease, this is an attempt to design a new drug, which is more specific for the gene product causing the Breast Cancer. Keywords: Breast Cancer, BRCA1, BASC, RNA polymerase II , C-terminal domain, histone deacetylase complex, Mutations. *Department of Biotechnology, Jawaharlal Nehru Technological University Anantapur College of Engineering Pulivendula, Pulvendula, Andhra Pradesh, INDIA. **Department of Biotechnology, Madanapalle Institute of Technology & Science, Madanapalle, Andhra Pradesh, INDIA.